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Abstract：
O-linked-β-D-N-acetylglucosamine (O-GlcNAc) glycosylation (O-GlcNAcylation), which is dynamically regulated by O-GlcNAc transferase (OGT) and O-GlcNAcase (OGA), is a post-translational modification involved in multiple cellular processes. O-GlcNAcylation of proteins can regulate their biological functions via crosstalk with other post-translational modifications, such as phosphorylation, ubiquitination, acetylation, and methylation. Liver diseases are a major cause of death worldwide; yet, key pathological features of the disease, such as inflammation, fibrosis, steatosis, and tumorigenesis, are not fully understood. The dysregulation of O-GlcNAcylation has been shown to be involved in some severe hepatic cellular stress, viral hepatitis, liver fibrosis, nonalcoholic fatty acid liver disease (NAFLD), malignant progression, and drug resistance of hepatocellular carcinoma (HCC) through multiple molecular signaling pathways. Here, we summarize the emerging link between O-GlcNAcylation and hepatic pathological processes and provide information about the development of therapeutic strategies for liver diseases.
摘要：
O-连接-β-D-N-乙酰葡糖胺（O-GlcNAc）糖基化（O-GlcNAcylation），由O-GlcNAc转移酶（OGT）和O-GlcNAcase（OGA）动态调节，是参与多个细胞过程的翻译后修饰。蛋白质的O-GlcNAcylation可以通过与其他翻译后修饰的串扰来调节其生物学功能，比如磷酸化，泛素化，乙酰化,和甲基化。肝脏疾病是全世界死亡的主要原因，该疾病的关键病理特征，比如炎症，纤维化，脂肪变性,和肿瘤发生，没有完全理解。O-GlcNAcylation的失调已被证明与一些严重的肝细胞应激有关。病毒性肝炎,肝纤维化,非酒精性脂肪酸肝病（NAFLD），恶性进展,肝细胞癌（HCC）的耐药通过多分子信号通路。这里,我们总结了O-GlcNAcylation与肝脏病理过程之间的新联系，并提供了有关肝病治疗策略发展的信息。
