PDF(Pubmed)
Abstract：
Protein ubiquitination is an enzymatic cascade reaction and serves as an important protein post-translational modification (PTM) that is involved in the vast majority of cellular life activities. The key enzyme in the ubiquitination process is E3 ubiquitin ligase (E3), which catalyzes the binding of ubiquitin (Ub) to the protein substrate and influences substrate specificity. In recent years, the relationship between the subfamily of neuron-expressed developmental downregulation 4 (NEDD4), which belongs to the E3 ligase system, and digestive diseases has drawn widespread attention. Numerous studies have shown that NEDD4 and NEDD4L of the NEDD4 family can regulate the digestive function, as well as a series of related physiological and pathological processes, by controlling the subsequent degradation of proteins such as PTEN, c-Myc, and P21, along with substrate ubiquitination. In this article, we reviewed the appropriate functions of NEDD4 and NEDD4L in digestive diseases including cell proliferation, invasion, metastasis, chemotherapeutic drug resistance, and multiple signaling pathways, based on the currently available research evidence for the purpose of providing new ideas for the prevention and treatment of digestive diseases.
摘要：
蛋白质泛素化是一种酶促级联反应，是一种重要的蛋白质翻译后修饰（PTM），参与绝大多数细胞生命活动。泛素化过程中的关键酶是E3泛素连接酶（E3），催化泛素（Ub）与蛋白质底物的结合并影响底物特异性。近年来,神经元表达的发育下调4（NEDD4）亚家族之间的关系，属于E3连接酶系统，消化系统疾病引起了人们的广泛关注。大量研究表明，NEDD4和NEDD4家族的NEDD4可以调节消化功能，以及一系列相关的生理和病理过程，通过控制蛋白质如PTEN的后续降解，c-Myc,和P21，以及底物泛素化。在这篇文章中,我们回顾了NEDD4和NEDD4L在消化系统疾病中的适当功能，包括细胞增殖，入侵,转移,化疗耐药，和多种信号通路，目的为消化系统疾病的防治提供新思路。
