关键词: cancer risk inflammation metabolic syndrome oncogenesis oxidative stress

来  源:   DOI:10.3390/biology13050352   PDF(Pubmed)

Abstract:
BACKGROUND: Individuals with metabolic syndrome exhibit simultaneously pro-thrombotic and pro-inflammatory conditions which more probably can lead to cardiovascular diseases progression, type 2 diabetes mellitus, and some types of cancer. The present scoping review is aimed at highlighting the association between cancer risk, inflammation, and metabolic syndrome.
METHODS: A search strategy was performed, mixing keywords and MeSH terms, such as \"Cancer Risk\", \"Inflammation\", \"Metabolic Syndrome\", \"Oncogenesis\", and \"Oxidative Stress\", and matching them through Boolean operators. A total of 20 manuscripts were screened for the present study. Among the selected papers, we identified some associations with breast cancer, colorectal cancer, esophageal adenocarcinoma, hepatocellular carcinoma (HCC), and cancer in general.
CONCLUSIONS: Cancer and its related progression may also depend also on a latent chronic inflammatory condition associated with other concomitant conditions, including type 2 diabetes mellitus, metabolic syndrome, and obesity. Therefore, prevention may potentially help individuals to protect themselves from cancer.
摘要:
背景:患有代谢综合征的个体同时表现出促血栓形成和促炎症状态,这更可能导致心血管疾病进展,2型糖尿病,和某些类型的癌症。本范围审查旨在强调癌症风险之间的关联,炎症,和代谢综合征。
方法:执行搜索策略,混合关键字和MeSH术语,如“癌症风险”,“炎症”,“代谢综合征”,“肿瘤发生”,和“氧化应激”,并通过布尔运算符匹配它们。本研究共筛选了20份手稿。在选定的论文中,我们确定了一些与乳腺癌的关联,结直肠癌,食管腺癌,肝细胞癌(HCC),和癌症一般。
结论:癌症及其相关进展也可能取决于与其他伴随疾病相关的潜在慢性炎症。包括2型糖尿病,代谢综合征,和肥胖。因此,预防可能有助于个人保护自己免受癌症的侵害。
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