Abstract:
This review aims to highlight the structures of ADAR proteins that have been crucial in the discernment of their functions and are relevant to future therapeutic development. ADAR proteins can correct or diversify genetic information, underscoring their pivotal contribution to protein diversity and the sophistication of neuronal networks. ADAR proteins have numerous functions in RNA editing independent roles and through the mechanisms of A-I RNA editing that continue to be revealed. Provided is a detailed examination of the ADAR family members-ADAR1, ADAR2, and ADAR3-each characterized by distinct isoforms that offer both structural diversity and functional variability, significantly affecting RNA editing mechanisms and exhibiting tissue-specific regulatory patterns, highlighting their shared features, such as double-stranded RNA binding domains (dsRBD) and a catalytic deaminase domain (CDD). Moreover, it explores ADARs\' extensive roles in immunity, RNA interference, and disease modulation, demonstrating their ambivalent nature in both the advancement and inhibition of diseases. Through this comprehensive analysis, the review seeks to underline the potential of targeting ADAR proteins in therapeutic strategies, urging continued investigation into their biological mechanisms and health implications.
摘要:
这篇综述旨在强调ADAR蛋白的结构,这些结构对识别其功能至关重要,并与未来的治疗发展有关。ADAR蛋白可以纠正或多样化遗传信息,强调了它们对蛋白质多样性和神经元网络复杂性的关键贡献。ADAR蛋白在RNA编辑中具有许多独立的功能,并通过A-IRNA编辑的机制不断被揭示。提供了对ADAR家族成员-ADAR1,ADAR2和ADAR3-各自的特征在于提供结构多样性和功能变异性的不同同种型的详细检查。显着影响RNA编辑机制并表现出组织特异性调控模式,突出它们的共同特征,例如双链RNA结合结构域(dsRBD)和催化脱氨酶结构域(CDD)。此外,它探讨了ADAR在免疫中的广泛作用,RNA干扰,和疾病调制,证明了它们在疾病的发展和抑制方面的矛盾性质。通过全面的分析,这篇综述旨在强调在治疗策略中靶向ADAR蛋白的潜力,敦促继续调查其生物学机制和健康影响。