PDF(Pubmed)
Abstract：
This case report describes the development of Progressive Multifocal Leukoencephalopathy (PML) in a 72-year-old male with relapsed/refractory multiple myeloma (RRMM), following a single dose of teclistamab amidst a COVID-19 infection. Shortly after starting teclistamab treatment, the patient developed symptoms, including fever, altered mental status, and right-sided paresis. A diagnosis of PML was confirmed through the detection of JC virus PCR in the cerebrospinal fluid. Our report emphasizes the occurrence of PML after only one dose of teclistamab and highlights teclistamab\'s potential for severe infectious complications, despite its promise in treating RRMM.
摘要：
该病例报告描述了72岁男性复发性/难治性多发性骨髓瘤（RRMM）的进行性多灶性白质脑病（PML）的发展。在COVID-19感染中服用单剂量的替列他单抗后。在开始使用testlistamab治疗后不久,病人出现症状,包括发烧,精神状态改变,和右侧麻痹。通过脑脊液中JC病毒PCR的检测证实了PML的诊断。我们的报告强调了PML的发生后，只有一个剂量的teclistamab和突出teclistamab的潜在的严重感染并发症，尽管它承诺治疗RRMM。
