Abstract：
Patchouli oil has exhibited remarkable efficacy in the treatment of colitis. However, its volatility and potential irritancy are often drawbacks when extensively used in clinical applications. Oil gel is a semisolid and thermoreversible system that has received extensive interest for its solubility enhancement, inhibition of bioactive component recrystallization, and the facilitation of controlled bioactive release. Therefore, we present a strategy to develop an oil gel formulation that addresses this multifaceted problem. Notably, a patchouli oil gel formulation was designed to solidify and trap patchouli oil into a spatially stable crystal-particle structure and colonic released delivery, which has an advantage of the stable structure and viscosity. The patchouli oil gel treatment of zebrafish with colitis improved goblet cells and decreased macrophages. Additionally, patchouli oil gel showed superior advantages for restoring the tissue barrier. Furthermore, our investigative efforts unveiled patchouli oil\'s influence on TRP channels, providing evidence for its potential role in mechanisms of anti-inflammatory action. While the journey continues, these preliminary revelations provide a robust foundation for considering the adoption of patchouli oil gel as a pragmatic intervention for managing colitis.
摘要：
广藿香油对结肠炎的治疗具有显著的疗效。然而,在临床应用中广泛使用时，其挥发性和潜在的刺激性通常是缺点。油凝胶是一种半固体和热可逆系统，因其溶解度增强而受到广泛关注，抑制生物活性成分的重结晶，以及促进生物活性物质的受控释放。因此,我们提出了一种策略来开发一种油凝胶配方，以解决这个多方面的问题。值得注意的是,广藿香油凝胶制剂被设计为固化和捕获广藿香油成空间稳定的晶体颗粒结构和结肠释放递送，其具有稳定的结构和粘度的优点。广藿香油凝胶治疗斑马鱼结肠炎改善杯状细胞并减少巨噬细胞。此外,广藿香油凝胶在恢复组织屏障方面显示出优越的优势。此外，我们的调查工作揭示了广藿香油对TRP渠道的影响，为其在抗炎作用机制中的潜在作用提供证据。当旅程继续时,这些初步发现为考虑采用广藿香油凝胶作为治疗结肠炎的务实干预措施提供了坚实的基础.
