PDF(Pubmed)
Abstract：
Lactate is a byproduct of glycolysis, and before the Warburg effect was revealed (in which glucose can be fermented in the presence of oxygen to produce lactate) it was considered a metabolic waste product. At present, lactate is not only recognized as a metabolic substrate that provides energy, but also as a signaling molecule that regulates cellular functions under pathophysiological conditions. Lactylation, a post‑translational modification, is involved in the development of various diseases, including inflammation and tumors. Liver disease is a major health challenge worldwide. In normal liver, there is a net lactate uptake caused by gluconeogenesis, exhibiting a higher net lactate clearance rate compared with any other organ. Therefore, abnormalities of lactate and lactate metabolism lead to the development of liver disease, and lactate and lactate metabolism‑related genes can be used for predicting the prognosis of liver disease. Targeting lactate production, regulating lactate transport and modulating lactylation may be potential treatment approaches for liver disease. However, currently there is not a systematic review that summarizes the role of lactate and lactate metabolism in liver diseases. In the present review, the role of lactate and lactate metabolism in liver diseases including liver fibrosis, non‑alcoholic fatty liver disease, acute liver failure and hepatocellular carcinoma was summarized with the aim to provide insights for future research.
摘要：
乳酸是糖酵解的副产物,在揭示Warburg效应之前（其中葡萄糖可以在氧气存在下发酵以产生乳酸），它被认为是代谢废物。目前,乳酸不仅被认为是提供能量的代谢底物，但也可以作为在病理生理条件下调节细胞功能的信号分子。Lactylation,翻译后修饰，参与了各种疾病的发展，包括炎症和肿瘤。肝病是全球范围内的重大健康挑战。在正常肝脏中，糖异生引起的乳酸净摄取，与任何其他器官相比，表现出较高的净乳酸清除率。因此,乳酸和乳酸代谢异常导致肝脏疾病的发展，乳酸和乳酸代谢相关基因可用于预测肝病的预后。以乳酸生产为目标，调节乳酸转运和调节乳酸化可能是治疗肝病的潜在方法。然而,目前还没有系统的综述来总结乳酸和乳酸代谢在肝脏疾病中的作用。在本次审查中，乳酸和乳酸代谢在肝脏疾病包括肝纤维化中的作用，非酒精性脂肪性肝病,总结了急性肝衰竭和肝细胞癌，旨在为未来的研究提供见解。
