PDF(Pubmed)
Abstract：
Migraine is a prevalent and disabling neurovascular disorder, with women being more susceptible, characterized by unilateral throbbing headache, often accompanied by nausea and vomiting, and often associated with various comorbidities such as brain and cardiovascular diseases, which can have a serious impact on quality of life. Although nonsteroidal anti-inflammatory drugs (NSAIDs) are the main first-line medications for the treatment of pain, long-term use often leads to side effects and drug addiction, which emphasizes the need to investigate alternative pain management strategies with fewer adverse effects. Complementary and alternative medicine is a viable pain intervention often used in conjunction with traditional medications, including acupuncture, herbs, moxibustion, transcutaneous electrical stimulation, bio-supplements, and acupressure, which offer non-pharmacological alternatives that are now viable pain management options. This review focuses on the mechanistic doctrine of migraine generation and the role and potential mechanisms of Complementary and Alternative Therapies (CAT) in the treatment of migraine, summarizes the research evidences for CAT as an adjunct or alternative to conventional therapies for migraine, and focuses on the potential of novel migraine therapies (calcitonin gene-related peptide (CGRP) antagonists and pituitary adenylyl cyclase-activating peptide (PACAP) antagonists) with the aim of evaluating CAT therapies as adjunctive or alternative therapies to conventional migraine treatment, thereby providing a broader perspective on migraine management and the design of treatment programs for more effective pain management.
摘要：
偏头痛是一种普遍和致残的神经血管疾病，女性更容易受到影响，以单侧搏动性头痛为特征，经常伴有恶心和呕吐，通常与各种合并症有关，例如脑部和心血管疾病，会对生活质量产生严重影响。尽管非甾体抗炎药（NSAIDs）是治疗疼痛的主要一线药物，长期使用往往会导致副作用和药物成瘾，强调需要研究副作用较少的替代疼痛管理策略.补充和替代医学是一种可行的疼痛干预措施，通常与传统药物结合使用。包括针灸,草药,艾灸,经皮电刺激,生物补充剂，和穴位按摩，它提供了非药物替代品，现在是可行的疼痛管理选择。这篇综述的重点是偏头痛产生的机制学说以及补充和替代疗法（CAT）在偏头痛治疗中的作用和潜在机制。总结了CAT作为偏头痛常规疗法的辅助或替代方法的研究证据，并专注于新型偏头痛疗法（降钙素基因相关肽（CGRP）拮抗剂和垂体腺苷酸环化酶激活肽（PACAP）拮抗剂）的潜力，目的是评估CAT疗法作为常规偏头痛治疗的辅助或替代疗法，从而为偏头痛的管理和更有效的疼痛管理的治疗方案的设计提供了更广阔的视野。
