PDF(Pubmed)
Abstract：
Anxiety disorder is a prevalent psychiatric issue that affects 4.05% of the global population. As complementary and alternative medicine gains popularity, many individuals with anxiety symptoms seek herbal remedies. This systematic review aims to explore the sedative efficacy of chamomile as an herbal medicine for anxiety treatment. Our search was conducted in PubMed, Google Scholar, and Scopus databases until August 2023. Among 389 papers found, after removing duplicates and irrelevant papers, 10 clinical trials investigating the effect of oral consumption of chamomile on anxiety were included. Two researchers independently completed all steps, including the screening process and data extraction. Out of the 10 articles selected, 9 studies have concluded that chamomile is effective in reducing anxiety. Even though, the exact mechanism of chamomile\'s anxiolytic action is not well understood, evidence suggests that its active compounds, including apigenin, may modulate the function of the hypothalamic-pituitary-adrenocortical axis by affecting neurotransmitter pathways. This systematic review showed that chamomile potentially has an anxiolytic effect. In addition, due to the side effects of drugs used to treat anxiety disorders, the use of chamomile seems to be effective and less dangerous.
摘要：
焦虑症是一种普遍的精神疾病，影响全球4.05％的人口。随着补充和替代医学的普及，许多有焦虑症状的人寻求草药。本系统综述旨在探讨洋甘菊作为治疗焦虑症的中草药的镇静效果。我们的搜索是在PubMed进行的,谷歌学者，和Scopus数据库，直到2023年8月。在发现的389篇论文中，删除副本和无关文件后，包括10项临床试验，研究口服洋甘菊对焦虑的影响。两名研究人员独立完成了所有步骤，包括筛选过程和数据提取。在所选的10篇文章中，9项研究得出结论，洋甘菊可以有效减少焦虑。即使,洋甘菊抗焦虑作用的确切机制尚不清楚，证据表明它的活性化合物，包括芹菜素,可能通过影响神经递质通路来调节下丘脑-垂体-肾上腺皮质轴的功能。这项系统评价表明洋甘菊可能具有抗焦虑作用。此外,由于用于治疗焦虑症的药物的副作用，洋甘菊的使用似乎是有效和不那么危险。
