PDF(Pubmed)
Abstract：
Introduction: Bone tumors, characterized by diverse locations and shapes, often necessitate surgical excision followed by custom implant placement to facilitate targeted bone reconstruction. Leveraging additive manufacturing, patient-specific implants can be precisely tailored with complex geometries and desired stiffness, enhancing their suitability for bone ingrowth. Methods: In this work, a finite element model is employed to assess patient-specific lattice implants in femur bones. Our model is validated using experimental data obtained from an animal study (n = 9). Results: The results demonstrate the accuracy of the proposed finite element model in predicting the implant mechanical behavior. The model was used to investigate the influence of reducing the elastic modulus of a solid Ti6Al4V implant by tenfold, revealing that such a reduction had no significant impact on bone behavior under maximum compression and torsion loading. This finding suggests a potential avenue for reducing the endoprosthesis modulus without compromising bone integrity. Discussion: Our research suggests that employing fully lattice implants not only facilitates bone ingrowth but also has the potential to reduce overall implant stiffness. This reduction is crucial in preventing significant bone remodeling associated with stress shielding, a challenge often associated with the high stiffness of fully solid implants. The study highlights the mechanical benefits of utilizing lattice structures in implant design for enhanced patient outcomes.
摘要：
简介：骨肿瘤，以不同的位置和形状为特征，通常需要手术切除，然后进行定制的植入物放置，以促进有针对性的骨骼重建。利用增材制造，患者特定的植入物可以精确地定制复杂的几何形状和所需的刚度，增强它们对骨骼向内生长的适应性。方法：在这项工作中，有限元模型用于评估股骨中患者特定的晶格植入物。使用从动物研究获得的实验数据(n=9)验证我们的模型。结果：结果证明了所提出的有限元模型在预测植入物力学行为方面的准确性。该模型用于研究将固体Ti6Al4V植入物的弹性模量降低十倍的影响，揭示了在最大压缩和扭转载荷下，这种减少对骨骼行为没有显着影响。这一发现表明了降低内置假体模量而不损害骨完整性的潜在途径。讨论：我们的研究表明，采用完全网格植入物不仅有助于骨骼向内生长，而且有可能降低整体植入物的刚度。这种减少对于防止与应力屏蔽相关的显著骨重建至关重要。通常与完全固体植入物的高刚度相关的挑战。该研究强调了在植入物设计中利用晶格结构来增强患者预后的机械优势。
