PDF(Pubmed)
Abstract：
Alzheimer\'s disease (AD) is a progressive neurodegenerative disorder characterized by cognitive decline, memory loss, and impaired daily functioning. While there is currently no cure for AD, several pharmacotherapeutic targets and management strategies have been explored. Additionally, traditional medicinal plants have gained attention for their potential role in AD management. Pharmacotherapeutic targets in AD include amyloid-beta (Aβ) aggregation, tau protein hyperphosphorylation, neuroinflammation, oxidative stress, and cholinergic dysfunction. Traditional medicinal plants, such as Ginkgo biloba, Huperzia serrata, Curcuma longa (turmeric), and Panax ginseng, have demonstrated the ability to modulate these targets through their bioactive compounds. Ginkgo biloba, for instance, contains flavonoids and terpenoids that exhibit neuroprotective effects by reducing Aβ deposition and enhancing cerebral blood flow. Huperzia serrata, a natural source of huperzine A, has acetylcholinesterase-inhibiting properties, thus improving cholinergic function. Curcuma longa, enriched with curcumin, exhibits anti-inflammatory and antioxidant effects, potentially mitigating neuroinflammation and oxidative stress. Panax ginseng\'s ginsenosides have shown neuroprotective and anti-amyloidogenic properties. The investigation of traditional medicinal plants as a complementary approach to AD management offers several advantages, including a lower risk of adverse effects and potential multi-target interactions. Furthermore, the cultural knowledge and utilization of these plants provide a rich source of information for the development of new therapies. However, further research is necessary to elucidate the precise mechanisms of action, standardize preparations, and assess the safety and efficacy of these natural remedies. Integrating traditional medicinal-plant-based therapies with modern pharmacotherapies may hold the key to a more comprehensive and effective approach to AD treatment. This review aims to explore the pharmacotherapeutic targets in AD and assess the potential of traditional medicinal plants in its management.
摘要：
阿尔茨海默病(AD)是一种以认知功能下降为特征的进行性神经退行性疾病,记忆丧失,和日常功能受损。虽然目前没有治愈AD的方法，已经探索了几种药物治疗目标和管理策略。此外,传统药用植物因其在AD管理中的潜在作用而受到关注。AD的药物治疗靶标包括淀粉样β（Aβ）聚集，tau蛋白过度磷酸化，神经炎症，氧化应激，和胆碱能功能障碍。传统药用植物,比如银杏叶,锯缘石杉,姜黄（姜黄），还有人参,已经证明了通过其生物活性化合物调节这些靶标的能力。银杏,例如,含有类黄酮和萜类化合物，通过减少Aβ沉积和增强脑血流量而表现出神经保护作用。锯缘石杉,石杉碱A的天然来源,具有抑制乙酰胆碱酯酶的特性，从而改善胆碱能功能。姜黄,富含姜黄素，具有抗炎和抗氧化作用，可能减轻神经炎症和氧化应激。人参的人参皂苷具有神经保护和抗淀粉样生成特性。调查传统药用植物作为AD管理的补充方法提供了几个优点，包括较低的不良反应风险和潜在的多靶点相互作用。此外，这些植物的文化知识和利用为开发新疗法提供了丰富的信息来源。然而,需要进一步的研究来阐明确切的作用机制，标准化制剂，并评估这些自然疗法的安全性和有效性。将传统的基于药用植物的疗法与现代药物疗法相结合可能是更全面和有效的AD治疗方法的关键。本文旨在探讨AD的药物治疗靶点，并评估传统药用植物在其管理中的潜力。
