PDF(Pubmed)
Abstract：
UNASSIGNED: Sickle cell anaemia (SCA) imposes a substantial healthcare burden, affecting millions of people worldwide. Understanding the determinants influencing SCA severity is crucial for enhanced disease management and optimized patient outcomes. This study aimed to investigate the relationship between Neutrophil-Lymphocyte Ratio (NLR), Platelet-Neutrophil Ratio (PNR), Platelet-Lymphocyte Ratio (PLR), and SCA severity.
UNASSIGNED: A cohort of 45 children diagnosed with SCA and undergoing treatment at Chukwuemeka Odumegwu Ojukwu University Teaching Hospital, Awka, was included in this study. Demographic and clinical data, along with laboratory measurements of the aforementioned ratios, were collected. The severity of SCA was assessed using numerical scoring.
UNASSIGNED: The analysis revealed that PNR and PLR emerged as significant predictors of SCA severity, irrespective of the level of adiposity. In contrast, NLR demonstrated no predictive value in relation to SCA severity.
UNASSIGNED: The findings challenge the conventional notion that neutrophils alone play a central role in the pathogenesis of sickle cell crises. These results contribute to a deeper understanding of the disease and provide insights into possible alternative mechanisms underlying SCA severity. Further research is warranted to explore the intricate interplay between platelets, neutrophils, lymphocytes, and other biological factors within the context of SCA. Ultimately, this knowledge may pave the way for targeted interventions and improved management strategies for individuals living with SCA.
UNASSIGNED: A cohort of 45 children diagnosed with SCA and undergoing treatment at Chukwuemeka Odumegwu Ojukwu University Teaching Hospital, Awka, was included in this study. Demographic and clinical data, along with laboratory measurements of the aforementioned ratios, were collected. The severity of SCA was assessed using numerical scoring.
UNASSIGNED: The analysis revealed that PNR and PLR emerged as significant predictors of SCA severity, irrespective of the level of adiposity. In contrast, NLR demonstrated no predictive value in relation to SCA severity.
UNASSIGNED: The findings challenge the conventional notion that neutrophils alone play a central role in the pathogenesis of sickle cell crises. These results contribute to a deeper understanding of the disease and provide insights into possible alternative mechanisms underlying SCA severity. Further research is warranted to explore the intricate interplay between platelets, neutrophils, lymphocytes, and other biological factors within the context of SCA. Ultimately, this knowledge may pave the way for targeted interventions and improved management strategies for individuals living with SCA.
摘要：
■镰状细胞贫血（SCA）带来了巨大的医疗保健负担，影响着全世界数百万人。了解影响SCA严重程度的决定因素对于加强疾病管理和优化患者预后至关重要。本研究旨在探讨中性粒细胞与淋巴细胞比值(NLR)之间的关系,血小板-中性粒细胞比值(PNR),血小板-淋巴细胞比率(PLR),和SCA严重性。
■45名被诊断为SCA并在ChukwuemekaOdumegwuOjukwu大学教学医院接受治疗的儿童，Awka,包括在这项研究中。人口统计学和临床数据，连同上述比率的实验室测量，被收集。使用数值评分评估SCA的严重程度。
■分析显示，PNR和PLR是SCA严重程度的重要预测因子，无论肥胖程度如何。相比之下,NLR对SCA严重程度无预测价值。
■这些发现挑战了传统的观点，即中性粒细胞在镰状细胞危象的发病机制中起着核心作用。这些结果有助于更深入地了解疾病，并提供对SCA严重程度的潜在替代机制的见解。需要进一步的研究来探索血小板之间复杂的相互作用，中性粒细胞，淋巴细胞，以及SCA背景下的其他生物学因素。最终,这些知识可能为有针对性的干预措施和改善SCA患者的管理策略铺平道路.
■45名被诊断为SCA并在ChukwuemekaOdumegwuOjukwu大学教学医院接受治疗的儿童，Awka,包括在这项研究中。人口统计学和临床数据，连同上述比率的实验室测量，被收集。使用数值评分评估SCA的严重程度。
■分析显示，PNR和PLR是SCA严重程度的重要预测因子，无论肥胖程度如何。相比之下,NLR对SCA严重程度无预测价值。
■这些发现挑战了传统的观点，即中性粒细胞在镰状细胞危象的发病机制中起着核心作用。这些结果有助于更深入地了解疾病，并提供对SCA严重程度的潜在替代机制的见解。需要进一步的研究来探索血小板之间复杂的相互作用，中性粒细胞，淋巴细胞，以及SCA背景下的其他生物学因素。最终,这些知识可能为有针对性的干预措施和改善SCA患者的管理策略铺平道路.
