PDF(Pubmed)
Abstract：
UNASSIGNED: Antibiotic resistance is a growing concern for bloodstream infections (BSIs), especially with the emergence of multidrug-resistant (MDR) gram-negative bacteria. In this study, we aimed to assess the pattern of colistin susceptibility using the colistin broth disc elution (CBDE) method among carbapenem-resistant gram-negative clinical isolates from blood cultures in a high burden tertiary healthcare setting in East Delhi.
UNASSIGNED: A total of 106 carbapenem-resistant gram-negative clinical isolates were tested. The most common isolates were Klebsiella pneumoniae, Escherichia coli, Enterobacter species, and Klebsiella oxytoca by CBDE method.
UNASSIGNED: All the carbapenem resistant gram-negative bacterial blood culture isolates showed intermediate colistin susceptibility. This was statistically significant by chi-square test (p<0.5).
UNASSIGNED: This study highlights the need to monitor colistin resistance trends in the face of increasing antimicrobial resistance. Accurate surveillance of emerging colistin resistance is crucial for effective management of BSIs caused by carbapenem-resistant gram-negative bacteria.
UNASSIGNED: A total of 106 carbapenem-resistant gram-negative clinical isolates were tested. The most common isolates were Klebsiella pneumoniae, Escherichia coli, Enterobacter species, and Klebsiella oxytoca by CBDE method.
UNASSIGNED: All the carbapenem resistant gram-negative bacterial blood culture isolates showed intermediate colistin susceptibility. This was statistically significant by chi-square test (p<0.5).
UNASSIGNED: This study highlights the need to monitor colistin resistance trends in the face of increasing antimicrobial resistance. Accurate surveillance of emerging colistin resistance is crucial for effective management of BSIs caused by carbapenem-resistant gram-negative bacteria.
摘要：
■抗生素耐药性是血液感染（BSIs）日益关注的问题，特别是随着多重耐药（MDR）革兰氏阴性菌的出现。在这项研究中,我们的目的是使用粘菌素肉汤纸片洗脱(CBDE)方法,在新德里高负担三级医疗机构的血培养物中碳青霉烯类耐药革兰阴性临床分离株中,评估粘菌素敏感性模式.
■总共测试了106株耐碳青霉烯类革兰氏阴性临床分离株。最常见的分离株是肺炎克雷伯菌，大肠杆菌,肠杆菌属物种,CBDE法检测氧化克雷伯菌。
■所有耐碳青霉烯类革兰阴性菌血培养分离株显示中等粘菌素敏感性。这通过卡方检验是统计学上显著的(p<0.5)。
■本研究强调了在抗菌素耐药性增加的情况下监测粘菌素耐药性趋势的必要性。对新出现的粘菌素耐药性的准确监测对于有效管理由耐碳青霉烯类革兰氏阴性菌引起的BSI至关重要。
■总共测试了106株耐碳青霉烯类革兰氏阴性临床分离株。最常见的分离株是肺炎克雷伯菌，大肠杆菌,肠杆菌属物种,CBDE法检测氧化克雷伯菌。
■所有耐碳青霉烯类革兰阴性菌血培养分离株显示中等粘菌素敏感性。这通过卡方检验是统计学上显著的(p<0.5)。
■本研究强调了在抗菌素耐药性增加的情况下监测粘菌素耐药性趋势的必要性。对新出现的粘菌素耐药性的准确监测对于有效管理由耐碳青霉烯类革兰氏阴性菌引起的BSI至关重要。
