PDF(Pubmed)
Abstract：
UNASSIGNED: Non-tuberculous mycobacteria (NTM) have been reported to cause pulmonary and extrapulmonary infections. These NTMs are often misdiagnosed as MTB due to their similar clinical presentations to tuberculosis, leading to inappropriate treatment and increased morbidity and mortality rates. This literature review aims to provide an overview of the prevalence, clinical manifestations, diagnosis, and management of NTM infections in Africa.
UNASSIGNED: A systematic search was performed using various electronic databases including PubMed, Scopus, and Web of Science. The search was limited to studies published in the English language from 2000 to 2021. The following keywords were used: \"non-tuberculous mycobacteria\", \"NTM\", \"Africa\", and \"prevalence\". Studies that focused solely on the Mycobacterium tuberculosis complex or those that did not report prevalence rates were excluded. Data extraction was performed on eligible studies. Overall, a total of 32 studies met the inclusion criteria and were included in this review.
UNASSIGNED: In our literature review, we identified a total of 32 studies that reported non-tuberculosis mycobacteria (NTM) in Africa. The majority of these studies were conducted in South Africa, followed by Ethiopia and Nigeria. The most commonly isolated NTM species were Mycobacterium avium complex (MAC), Mycobacterium fortuitum, and Mycobacterium abscessus. Many of the studies reported a high prevalence of NTM infections among HIV-positive individuals. Other risk factors for NTM infection included advanced age, chronic lung disease, and previous tuberculosis infection.
UNASSIGNED: In conclusion, this literature review highlights the significant burden of non-tuberculosis mycobacteria infections in Africa. The prevalence of these infections is high, and they are often misdiagnosed due to their similarity to tuberculosis. The lack of awareness and diagnostic tools for non-tuberculosis mycobacteria infections in Africa is a major concern that needs to be addressed urgently. It is crucial to improve laboratory capacity and develop appropriate diagnostic algorithms for these infections.
UNASSIGNED: A systematic search was performed using various electronic databases including PubMed, Scopus, and Web of Science. The search was limited to studies published in the English language from 2000 to 2021. The following keywords were used: \"non-tuberculous mycobacteria\", \"NTM\", \"Africa\", and \"prevalence\". Studies that focused solely on the Mycobacterium tuberculosis complex or those that did not report prevalence rates were excluded. Data extraction was performed on eligible studies. Overall, a total of 32 studies met the inclusion criteria and were included in this review.
UNASSIGNED: In our literature review, we identified a total of 32 studies that reported non-tuberculosis mycobacteria (NTM) in Africa. The majority of these studies were conducted in South Africa, followed by Ethiopia and Nigeria. The most commonly isolated NTM species were Mycobacterium avium complex (MAC), Mycobacterium fortuitum, and Mycobacterium abscessus. Many of the studies reported a high prevalence of NTM infections among HIV-positive individuals. Other risk factors for NTM infection included advanced age, chronic lung disease, and previous tuberculosis infection.
UNASSIGNED: In conclusion, this literature review highlights the significant burden of non-tuberculosis mycobacteria infections in Africa. The prevalence of these infections is high, and they are often misdiagnosed due to their similarity to tuberculosis. The lack of awareness and diagnostic tools for non-tuberculosis mycobacteria infections in Africa is a major concern that needs to be addressed urgently. It is crucial to improve laboratory capacity and develop appropriate diagnostic algorithms for these infections.
摘要：
据报道，非结核分枝杆菌（NTM）会引起肺部和肺外感染。这些NTM通常被误诊为MTB，因为它们的临床表现与结核病相似，导致不适当的治疗和增加的发病率和死亡率。这篇文献综述旨在提供患病率的概述，临床表现，诊断,以及非洲NTM感染的管理。
■使用包括PubMed在内的各种电子数据库进行了系统搜索，Scopus,和WebofScience。搜索仅限于2000年至2021年以英语发表的研究。使用了以下关键词：“非结核分枝杆菌”，\"NTM\",\"非洲\",和“患病率”。仅针对结核分枝杆菌群或未报告患病率的研究被排除。对符合条件的研究进行数据提取。总的来说,共有32项研究符合纳入标准,被纳入本综述.
■在我们的文献综述中，我们确定了总共32项报告非洲非结核分枝杆菌(NTM)的研究.这些研究大多在南非进行，其次是埃塞俄比亚和尼日利亚。最常见的分离的NTM物种是鸟分枝杆菌复合物（MAC），偶发分枝杆菌,和脓肿分枝杆菌.许多研究报道了HIV阳性个体中NTM感染的高患病率。NTM感染的其他危险因素包括高龄，慢性肺病,和以前的结核病感染。
■总而言之，这篇文献综述强调了非洲非结核分枝杆菌感染的重大负担.这些感染的患病率很高，由于它们与结核病相似，它们经常被误诊。非洲缺乏对非结核分枝杆菌感染的认识和诊断工具是一个迫切需要解决的主要问题。提高实验室能力并为这些感染开发适当的诊断算法至关重要。
■使用包括PubMed在内的各种电子数据库进行了系统搜索，Scopus,和WebofScience。搜索仅限于2000年至2021年以英语发表的研究。使用了以下关键词：“非结核分枝杆菌”，\"NTM\",\"非洲\",和“患病率”。仅针对结核分枝杆菌群或未报告患病率的研究被排除。对符合条件的研究进行数据提取。总的来说,共有32项研究符合纳入标准,被纳入本综述.
■在我们的文献综述中，我们确定了总共32项报告非洲非结核分枝杆菌(NTM)的研究.这些研究大多在南非进行，其次是埃塞俄比亚和尼日利亚。最常见的分离的NTM物种是鸟分枝杆菌复合物（MAC），偶发分枝杆菌,和脓肿分枝杆菌.许多研究报道了HIV阳性个体中NTM感染的高患病率。NTM感染的其他危险因素包括高龄，慢性肺病,和以前的结核病感染。
■总而言之，这篇文献综述强调了非洲非结核分枝杆菌感染的重大负担.这些感染的患病率很高，由于它们与结核病相似，它们经常被误诊。非洲缺乏对非结核分枝杆菌感染的认识和诊断工具是一个迫切需要解决的主要问题。提高实验室能力并为这些感染开发适当的诊断算法至关重要。
