PDF(Pubmed)
Abstract：
Polyunsaturated fatty acids (PUFAs) are vital nutrients in human physiology and are implicated in various chronic diseases. However, the relationship between PUFAs and gastric polyps remains unclear. This study employed liquid chromatography-tandem mass spectrometry (LC-MS/MS) to assess PUFA levels in the serum of 350 patients, along with analyzing the ω-6 to ω-3 ratio. The results revealed significant differences in the levels of C16:1, C18:1, C18:2, α-C18:3, γ-C18:3, C20:1, C20:4, C20:5, ω-3-C22:5, ω-6-C22:5, and C22:6, as well as ω-6 to ω-3 ratio between the control and gasteic polyp groups. Moreover, setting the threshold for ω-6: ω-3 at 10 revealed a close correlation between polyp occurrence and this ratio. These findings suggest that PUFAs and the ω-6 to ω-3 ratio hold promise as potential early screening markers for gastric polyps. However, further research is imperative to elucidate the underlying mechanisms and therapeutic potential of PUFAs in managing gastric polyps.
摘要：
多不饱和脂肪酸（PUFA）是人体生理中的重要营养素，并与各种慢性疾病有关。然而,PUFA与胃息肉之间的关系尚不清楚.本研究采用液相色谱-串联质谱（LC-MS/MS）评估350例患者血清中的PUFA水平，同时分析ω-6与ω-3的比值。结果表明，C16：1，C18：1，C18：2，α-C18：3，γ-C18：3，C20：1，C20：4，C20：5，ω-3-C22：5，ω-6-C22：5和C22：6的水平以及ω-6与ω-3的比例在对照和保守息肉组之间存在显着差异。此外，将ω-6:ω-3的阈值设定为10表明息肉的发生率与该比率密切相关。这些发现表明PUFA和ω-6与ω-3的比率有望作为胃息肉的潜在早期筛查标志物。然而,进一步的研究对于阐明PUFAs治疗胃息肉的潜在机制和治疗潜力至关重要.
