PDF(Pubmed)
Abstract：
UNASSIGNED: Carbapenem-resistant Enterobacterales (CRE) are considered urgent, antibiotic-resistant threats in the U.S. and are of global concern. Active collaboration between public health authorities and healthcare facilities and providers will be necessary to prevent and contain these organisms.
UNASSIGNED: To describe the epidemiology of CRE in Kentucky and to discuss challenges and successes with building and sustaining an effective prevention and containment program.
UNASSIGNED: Retrospective descriptive summary of CRE isolates reported by healthcare providers, facilities, and laboratories in Kentucky from 2013 through 2020. Data available from case reporting forms and laboratory testing are summarized.
UNASSIGNED: From 2013 through 2020, 1805 CRE were reported from 1666 individuals; median age was 66 years and 44% were male. Although most reports were from hospitalized individuals, nearly one-third were from individuals not hospitalized in acute-care hospital settings. The number of reports generally increased over time, with 111 CRE isolates in 2013 and 477 in 2020. Klebsiella pneumoniae was the most frequently reported CRE. Of the 29% of CRE with identified carbapenemase production (CP-CRE), Klebsiella pneumoniae carbapenemase (KPC) was most common (78%). Surveillance and reporting resulted in identification and active investigation of 11 outbreaks of CP-CRE.
UNASSIGNED: There are challenges with developing, implementing, and sustaining a consistent, effective response to identifying, preventing, and containing CRE. Ongoing public health and facility resources will be necessary to prevent and contain antibiotic-resistant threats and other concerning organisms.
UNASSIGNED: To describe the epidemiology of CRE in Kentucky and to discuss challenges and successes with building and sustaining an effective prevention and containment program.
UNASSIGNED: Retrospective descriptive summary of CRE isolates reported by healthcare providers, facilities, and laboratories in Kentucky from 2013 through 2020. Data available from case reporting forms and laboratory testing are summarized.
UNASSIGNED: From 2013 through 2020, 1805 CRE were reported from 1666 individuals; median age was 66 years and 44% were male. Although most reports were from hospitalized individuals, nearly one-third were from individuals not hospitalized in acute-care hospital settings. The number of reports generally increased over time, with 111 CRE isolates in 2013 and 477 in 2020. Klebsiella pneumoniae was the most frequently reported CRE. Of the 29% of CRE with identified carbapenemase production (CP-CRE), Klebsiella pneumoniae carbapenemase (KPC) was most common (78%). Surveillance and reporting resulted in identification and active investigation of 11 outbreaks of CP-CRE.
UNASSIGNED: There are challenges with developing, implementing, and sustaining a consistent, effective response to identifying, preventing, and containing CRE. Ongoing public health and facility resources will be necessary to prevent and contain antibiotic-resistant threats and other concerning organisms.
摘要：
■耐碳青霉烯类肠杆菌（CRE）被认为是紧急的，抗生素耐药威胁在美国和全球关注。公共卫生当局与医疗机构和提供者之间的积极合作对于预防和遏制这些生物是必要的。
■描述肯塔基州CRE的流行病学，并讨论建立和维持有效的预防和遏制计划的挑战和成功。
■医疗保健提供者报告的CRE分离株的回顾性描述性摘要，设施,以及2013年至2020年在肯塔基州的实验室。总结了病例报告表和实验室测试中提供的数据。
■从2013年到2020年，从1666个人报告了1805个CRE；平均年龄为66岁，男性占44％。尽管大多数报告来自住院患者，近1/3来自未在急诊医院住院的患者.报告数量普遍随着时间的推移而增加,2013年有111株CRE分离株，2020年有477株。肺炎克雷伯菌是最常见的CRE。在29％的具有碳青霉烯酶生产（CP-CRE）的CRE中，肺炎克雷伯菌碳青霉烯酶（KPC）最常见（78％）。监测和报告导致对11起CP-CRE暴发的识别和积极调查。
■发展面临挑战，实施，并保持一致，有效应对识别，预防,含有CRE。持续的公共卫生和设施资源对于预防和遏制抗生素抗性威胁和其他有关生物体将是必要的。
■描述肯塔基州CRE的流行病学，并讨论建立和维持有效的预防和遏制计划的挑战和成功。
■医疗保健提供者报告的CRE分离株的回顾性描述性摘要，设施,以及2013年至2020年在肯塔基州的实验室。总结了病例报告表和实验室测试中提供的数据。
■从2013年到2020年，从1666个人报告了1805个CRE；平均年龄为66岁，男性占44％。尽管大多数报告来自住院患者，近1/3来自未在急诊医院住院的患者.报告数量普遍随着时间的推移而增加,2013年有111株CRE分离株，2020年有477株。肺炎克雷伯菌是最常见的CRE。在29％的具有碳青霉烯酶生产（CP-CRE）的CRE中，肺炎克雷伯菌碳青霉烯酶（KPC）最常见（78％）。监测和报告导致对11起CP-CRE暴发的识别和积极调查。
■发展面临挑战，实施，并保持一致，有效应对识别，预防,含有CRE。持续的公共卫生和设施资源对于预防和遏制抗生素抗性威胁和其他有关生物体将是必要的。
