PDF(Pubmed)
Abstract：
Protein glycosylation is an extensively studied field, with the most studied forms being oxygen or nitrogen-linked N-acetylglucosamine (O-GlcNAc or N-GlcNAc) glycosylation. Particular residues on proteins are targeted by O-GlcNAcylation, which is among the most intricate post-translational modifications. Significantly contributing to an organism\'s proteome, it influences numerous factors affecting protein stability, function, and subcellular localization. It also modifies the cellular function of target proteins that have crucial responsibilities in controlling pathways related to the central nervous system, cardiovascular homeostasis, and other organ functions. Under conditions of acute stress, changes in the levels of O-GlcNAcylation of these proteins may have a defensive function. Nevertheless, deviant O-GlcNAcylation nullifies this safeguard and stimulates the advancement of several ailments, the prognosis of which relies on the cellular milieu. Hence, this review provides a concise overview of the function and comprehension of O-GlcNAcylation in ischemia diseases, aiming to facilitate the discovery of new therapeutic targets for efficient treatment, particularly in patients with diabetes.
摘要：
蛋白质糖基化是一个广泛研究的领域，研究最多的形式是氧或氮连接的N-乙酰葡糖胺（O-GlcNAc或N-GlcNAc）糖基化。蛋白质上的特定残基通过O-GlcNAcylation靶向，这是最复杂的翻译后修饰之一。显著有助于生物体的蛋白质组，它影响许多影响蛋白质稳定性的因素，函数,和亚细胞定位。它还改变了靶蛋白的细胞功能，这些靶蛋白在控制与中枢神经系统有关的通路中起着至关重要的作用。心血管稳态，和其他器官功能。在急性应激条件下，这些蛋白质的O-GlcNAcylation水平的变化可能具有防御功能。然而，异常的O-GlcNAcylation使这种保障无效，并刺激了几种疾病的发展，其预后依赖于细胞环境。因此，这篇综述简要概述了O-GlcNAcylation在缺血性疾病中的功能和理解，旨在促进发现有效治疗的新治疗靶点，特别是糖尿病患者。
