Abstract：
Along with infecting hepatocytes, the Hepatitis C virus (HCV) is also a lymphotropic virus. Chronic HCV infection can mutate the Bcl2, a proto-oncogene that inhibits apoptosis. This causes continuous stimulation of B lymphocytes, which results in clonal growth of these immunoglobulin-producing cells. In Western countries, there is a well-documented link between HCV and lymphoproliferative illness. HCV and Non-Hodgkin lymphoma (NHL) have been found to be significantly correlated in Europe, Japan, and the southern United States. There, however, has been no association found in central and northern Europe, the northwestern United States, and some Asian countries. A literature deficit exists in South Asia about the incidence of HCV infection in lymphoma patients. Here, the first documented instance of Diffuse Large B-cell NHL (germinal center type) is reported in a 35-year-old patient. The patient presented to the outpatient department at Ruth KM Pfau, Civil Hospital Karachi, in July of 2022, with the chief complaints of altered bowel habits due to involvement of the anorectal junction and concomitant infection by Helicobacter pylori with a prior history of HCV infection.
摘要：
随着肝细胞的感染，丙型肝炎病毒（HCV）也是一种嗜淋巴细胞病毒。慢性HCV感染可使抑制细胞凋亡的原癌基因Bcl2突变。这导致B淋巴细胞的持续刺激，导致这些产生免疫球蛋白的细胞克隆生长。在西方国家,HCV与淋巴组织增生性疾病之间有明确的联系.HCV和非霍奇金淋巴瘤（NHL）在欧洲被发现显著相关，Japan,和美国南部。在那里,然而,在中欧和北欧没有发现关联，美国西北部，和一些亚洲国家。南亚存在关于淋巴瘤患者HCV感染发生率的文献不足。这里,首次有文献记载的弥漫性大B细胞NHL(生发中心型)发生在一名35岁患者中.病人到露丝KMPfau门诊部就诊，卡拉奇市民医院，2022年7月，主要主诉是由于肛门直肠交界处受累以及有HCV感染史的幽门螺杆菌合并感染而改变了排便习惯。
