Abstract：
Sepsis is a potentially fatal illness marked by organ failure and the two main causes of which are shock and disseminated intravascular coagulation. Multi-organ dysfunction in sepsis is mediated by the inflammatory cytokine storm, while sepsis induced coagulopathy is mediated and accelerated by activation of pro-coagulative mechanisms. Regardless of the severity of sepsis, disseminated intravascular coagulation is a potent predictor of mortality in septic patients. Additionally, oxidative stress in sepsis causes renal ischaemia and eventually acute kidney injury. The first and foremost goal is to initiate resuscitation immediately, with treatment mainly focussing on maintaining a balance of coagulants and anticoagulants. A simpler and more universal diagnostic criteria is likely to improve studies on the spectrum associated with sepsis.
摘要：
脓毒症是一种以器官衰竭为特征的潜在致命疾病，其两个主要原因是休克和弥散性血管内凝血。脓毒症多器官功能障碍是由炎症细胞因子风暴介导的,而脓毒症诱导的凝血障碍是通过激活促凝机制介导和加速的。不管脓毒症的严重程度如何,弥散性血管内凝血是脓毒症患者死亡率的有效预测指标.此外,败血症中的氧化应激会导致肾缺血并最终导致急性肾损伤。首要目标是立即开始复苏，治疗主要集中在维持凝血剂和抗凝剂的平衡。更简单和更通用的诊断标准可能会改善与脓毒症相关的频谱研究。
