PDF(Pubmed)
Abstract：
BACKGROUND: Limited studies are available on vitamin D supplementation in dogs. This study evaluates the effect of a commercial vitamin D3 supplement on serum 25-hydroxy vitamin D as well as selected biochemical and hematological parameters in healthy dogs. Eight intact male adult dogs with a mean body weight of 20 kg from mixed breeds were included in the study. After adaptation period, dogs received vitamin D3 supplement at the dose of 50 IU/kg body weight per day. Blood samples were collected on days 0, 14, 28 and 42 of supplementation. Food was used for analysis of vitamin D3 content.
RESULTS: Significant increase in serum level of 25-hydroxy vitamin D3 was detected since day 14 of supplementation. Changes in serum 25-hydroxy vitamin D3 concentration during time showed an upward significance (p < 0.05). Vitamin D3 content of the food was 2900 IU/kg dry matter. Changes in serum phosphorus levels were upward significant. No dog showed calcium or phosphorus levels above the highest reference level. Liver and kidney parameters remained in the reference range during the experiment. A gradual significant increase was observed in hemoglobin and hematocrit which was started from day 14. Vitamin D3 supplementation had no significant effect on neutrophils, monocytes and lymphocytes percent during the study.
CONCLUSIONS: Vitamin D3 supplementation at 50 IU/kg BW daily, increases serum levels of 25-hydroxy vitamin D in healthy dogs fed with a diet containing proper amount of this vitamin. It also increases hemoglobin and hematocrit levels in a time dependent manner without inducing adverse effects.
RESULTS: Significant increase in serum level of 25-hydroxy vitamin D3 was detected since day 14 of supplementation. Changes in serum 25-hydroxy vitamin D3 concentration during time showed an upward significance (p < 0.05). Vitamin D3 content of the food was 2900 IU/kg dry matter. Changes in serum phosphorus levels were upward significant. No dog showed calcium or phosphorus levels above the highest reference level. Liver and kidney parameters remained in the reference range during the experiment. A gradual significant increase was observed in hemoglobin and hematocrit which was started from day 14. Vitamin D3 supplementation had no significant effect on neutrophils, monocytes and lymphocytes percent during the study.
CONCLUSIONS: Vitamin D3 supplementation at 50 IU/kg BW daily, increases serum levels of 25-hydroxy vitamin D in healthy dogs fed with a diet containing proper amount of this vitamin. It also increases hemoglobin and hematocrit levels in a time dependent manner without inducing adverse effects.
摘要：
背景：关于狗补充维生素D的研究有限。这项研究评估了商业维生素D3补充剂对健康狗的血清25-羟基维生素D以及选定的生化和血液学参数的影响。研究中包括来自混合品种的八只完整的雄性成年狗，平均体重为20kg。适应期后,狗接受维生素D3补充剂的剂量为每天50IU/kg体重.在补充的第0、14、28和42天收集血样。食物用于维生素D3含量的分析。
结果：自补充第14天以来，检测到25-羟基维生素D3的血清水平显着增加。血清25-羟基维生素D3浓度在一段时间内的变化显示出向上的显著性(p<0.05)。食物的维生素D3含量为2900IU/kg干物质。血清磷水平的变化明显向上。没有狗显示钙或磷水平高于最高参考水平。在实验期间,肝脏和肾脏参数保持在参考范围内。从第14天开始,观察到血红蛋白和血细胞比容逐渐显著增加。补充维生素D3对中性粒细胞没有显著影响，研究期间单核细胞和淋巴细胞百分比。
结论：每天补充50IU/kg体重的维生素D3，增加25-羟基维生素D的血清水平在健康狗饲喂含有适量的这种维生素的饮食。它还以时间依赖性方式增加血红蛋白和血细胞比容水平,而不引起副作用。
结果：自补充第14天以来，检测到25-羟基维生素D3的血清水平显着增加。血清25-羟基维生素D3浓度在一段时间内的变化显示出向上的显著性(p<0.05)。食物的维生素D3含量为2900IU/kg干物质。血清磷水平的变化明显向上。没有狗显示钙或磷水平高于最高参考水平。在实验期间,肝脏和肾脏参数保持在参考范围内。从第14天开始,观察到血红蛋白和血细胞比容逐渐显著增加。补充维生素D3对中性粒细胞没有显著影响，研究期间单核细胞和淋巴细胞百分比。
结论：每天补充50IU/kg体重的维生素D3，增加25-羟基维生素D的血清水平在健康狗饲喂含有适量的这种维生素的饮食。它还以时间依赖性方式增加血红蛋白和血细胞比容水平,而不引起副作用。
