Abstract：
OBJECTIVE: The purpose of this study was to evaluate the optic disc and macula in a large cohort of patients with different severity of optic nerve hypoplasia (ONH) using high-resolution spectral domain optical coherence tomography (SD-OCT).
METHODS: In total, 36 patients (52 ONH eyes and 17 fellow eyes in unilateral cases) and 45 healthy right eyes from 45 controls were evaluated. All patients underwent an examination to confirm the diagnosis. SD-OCT images of the disc and macula were obtained and analysed both quantitatively and qualitatively.
RESULTS: OCT in ONH eyes demonstrated a shorter disc diameter (1061 ± 375 μm vs. 1751 ± 221 μm, p < 0.001), shallower mean cup depth (427 ± 171 μm vs. 551 ± 152 μm, p = 0.01), thinner ganglion cell complex (GCC) perifoveally (47.3 ± 13.0 μm, 60.8 ± 6.0 μm, p < 0.001) and reduced foveal depth (61 ± 36 μm, 119 ± 19 μm, p < 0.001) compared to control eyes. Qualitative analysis showed that 1/3rd of ONH eyes lacked signs of an optic cup, and 2/3rd had reduced or no sign of a foveal pit. Fellow eyes had shorter disc diameter (1446 ± 404 μm vs. 1751 ± 221 μm, p = 0.004) and reduced foveal depth (93 ± 27 μm vs. 119 ± 19 μm, p < 0.001) but similar GCC thickness (60.8 ± 7.1 μm vs. 60.8 ± 6.0 μm, p = 0.738) compared to controls. Disc diameter showed the best correlation with visual acuity in ONH eyes (ρ = 0.517, p < 0.001).
CONCLUSIONS: ONH eyes have reduced GCC thickness and reduced or no foveal pit. Fellow eyes in presumed unilateral cases have a smaller disc diameter and reduced foveal depth compared to controls, suggesting the possibility of subclinical/mild disease. However, GCC thickness was normal. The correlation between structure and visual function is not always straightforward.
METHODS: In total, 36 patients (52 ONH eyes and 17 fellow eyes in unilateral cases) and 45 healthy right eyes from 45 controls were evaluated. All patients underwent an examination to confirm the diagnosis. SD-OCT images of the disc and macula were obtained and analysed both quantitatively and qualitatively.
RESULTS: OCT in ONH eyes demonstrated a shorter disc diameter (1061 ± 375 μm vs. 1751 ± 221 μm, p < 0.001), shallower mean cup depth (427 ± 171 μm vs. 551 ± 152 μm, p = 0.01), thinner ganglion cell complex (GCC) perifoveally (47.3 ± 13.0 μm, 60.8 ± 6.0 μm, p < 0.001) and reduced foveal depth (61 ± 36 μm, 119 ± 19 μm, p < 0.001) compared to control eyes. Qualitative analysis showed that 1/3rd of ONH eyes lacked signs of an optic cup, and 2/3rd had reduced or no sign of a foveal pit. Fellow eyes had shorter disc diameter (1446 ± 404 μm vs. 1751 ± 221 μm, p = 0.004) and reduced foveal depth (93 ± 27 μm vs. 119 ± 19 μm, p < 0.001) but similar GCC thickness (60.8 ± 7.1 μm vs. 60.8 ± 6.0 μm, p = 0.738) compared to controls. Disc diameter showed the best correlation with visual acuity in ONH eyes (ρ = 0.517, p < 0.001).
CONCLUSIONS: ONH eyes have reduced GCC thickness and reduced or no foveal pit. Fellow eyes in presumed unilateral cases have a smaller disc diameter and reduced foveal depth compared to controls, suggesting the possibility of subclinical/mild disease. However, GCC thickness was normal. The correlation between structure and visual function is not always straightforward.
摘要：
目的：本研究的目的是使用高分辨率谱域光学相干断层扫描（SD-OCT）评估大量不同严重程度视神经发育不全（ONH）患者的视盘和黄斑。
方法：总共，评估了36例患者（单侧病例为52只ONH眼和17只同眼）和45只健康右眼。所有患者均接受检查以确认诊断。获得了椎间盘和黄斑的SD-OCT图像，并进行了定量和定性分析。
结果：ONH眼中的OCT显示出更短的椎间盘直径（1061±375μmvs.1751±221μm,p<0.001)，较浅的平均杯深（427±171μmvs.551±152μm,p=0.01),中心凹周围较薄的神经节细胞复合体（GCC）（47.3±13.0μm，60.8±6.0μm,p<0.001)和减少的中央凹深度(61±36μm，119±19μm,p<0.001)与对照眼相比。定性分析显示，1/3的ONH眼睛缺乏视杯的迹象，和2/3减少或没有中央凹的迹象。其他眼睛的椎间盘直径较短（1446±404μm与1751±221μm,p=0.004）和减少的中央凹深度（93±27μmvs.119±19μm,p<0.001），但GCC厚度相似（60.8±7.1μm与60.8±6.0μm,p=0.738）与对照组相比。ONH眼的视盘直径与视力的相关性最好（ρ=0.517，p<0.001）。
结论：ONH眼的GCC厚度减少，中央凹凹陷减少或没有。与对照组相比，假定的单侧病例的同侧眼睛具有较小的椎间盘直径和减小的中央凹深度。提示亚临床/轻度疾病的可能性。然而,GCC厚度正常。结构和视觉功能之间的关系并不总是简单的。
方法：总共，评估了36例患者（单侧病例为52只ONH眼和17只同眼）和45只健康右眼。所有患者均接受检查以确认诊断。获得了椎间盘和黄斑的SD-OCT图像，并进行了定量和定性分析。
结果：ONH眼中的OCT显示出更短的椎间盘直径（1061±375μmvs.1751±221μm,p<0.001)，较浅的平均杯深（427±171μmvs.551±152μm,p=0.01),中心凹周围较薄的神经节细胞复合体（GCC）（47.3±13.0μm，60.8±6.0μm,p<0.001)和减少的中央凹深度(61±36μm，119±19μm,p<0.001)与对照眼相比。定性分析显示，1/3的ONH眼睛缺乏视杯的迹象，和2/3减少或没有中央凹的迹象。其他眼睛的椎间盘直径较短（1446±404μm与1751±221μm,p=0.004）和减少的中央凹深度（93±27μmvs.119±19μm,p<0.001），但GCC厚度相似（60.8±7.1μm与60.8±6.0μm,p=0.738）与对照组相比。ONH眼的视盘直径与视力的相关性最好（ρ=0.517，p<0.001）。
结论：ONH眼的GCC厚度减少，中央凹凹陷减少或没有。与对照组相比，假定的单侧病例的同侧眼睛具有较小的椎间盘直径和减小的中央凹深度。提示亚临床/轻度疾病的可能性。然而,GCC厚度正常。结构和视觉功能之间的关系并不总是简单的。
