Abstract：
Pregnancy is a remarkable event where the semi-allogeneic fetus develops in the mother\'s uterus, despite genetic and immunological differences. The antigen handling and processing at the maternal-fetal interface during pregnancy appear to be crucial for the adaptation of the maternal immune system and for tolerance to the developing fetus and placenta. Maternal antigen-presenting cells (APCs), such as macrophages (Mφs) and dendritic cells (DCs), are present at the maternal-fetal interface throughout pregnancy and are believed to play a crucial role in this process. Despite numerous studies focusing on the significance of Mφs, there is limited knowledge regarding the contribution of DCs in fetomaternal tolerance during pregnancy, making it a relatively new and growing field of research. This review focuses on how the behavior of DCs at the maternal-fetal interface adapts to pregnancy\'s unique demands. Moreover, it discusses how DCs interact with other cells in the decidual leukocyte network to regulate uterine and placental homeostasis and the local maternal immune responses to the fetus. The review particularly examines the different cell lineages of DCs with specific surface markers, which have not been critically reviewed in previous publications. Additionally, it emphasizes the impact that even minor disruptions in DC functions can have on pregnancy-related complications and proposes further research into the potential therapeutic benefits of targeting DCs to manage these complications.
摘要：
怀孕是一个值得注意的事件，半同种异体胎儿在母亲的子宫中发育，尽管遗传和免疫学差异。怀孕期间母胎界面处的抗原处理和处理似乎对于母体免疫系统的适应以及对发育中的胎儿和胎盘的耐受性至关重要。母体抗原呈递细胞（APC），如巨噬细胞（Mφs）和树突状细胞（DC），在整个怀孕期间存在于母胎界面，并被认为在这一过程中起着至关重要的作用。尽管许多研究都集中在Mφs的意义上，关于怀孕期间DCs在胎儿耐受中的贡献的知识有限，使其成为一个相对较新的不断发展的研究领域。这篇综述集中在母胎界面的DCs行为如何适应妊娠的独特需求。此外，它讨论了DC如何与蜕膜白细胞网络中的其他细胞相互作用，以调节子宫和胎盘的稳态以及母体对胎儿的局部免疫反应。该综述特别检查了具有特定表面标记的DC的不同细胞系，在以前的出版物中没有严格审查过。此外,它强调了即使DC功能的轻微破坏也可能对妊娠相关并发症产生的影响,并提出了针对DC治疗这些并发症的潜在治疗益处的进一步研究.
