Abstract：
Pregnancy is a transformative period marked by profound physical and emotional changes, with far-reaching consequences for both mother and child. Emerging research has illustrated the pivotal role of a mother\'s diet during pregnancy in influencing the prenatal gut microbiome and subsequently shaping the neurodevelopment of her offspring. The intricate interplay between maternal gut health, nutrition, and neurodevelopmental outcomes has emerged as a captivating field of investigation within developmental science. Acting as a dynamic bridge between mother and fetus, the maternal gut microbiome, directly and indirectly, impacts the offspring\'s neurodevelopment through diverse pathways. This comprehensive review delves into a spectrum of studies, clarifying putative mechanisms through which maternal nutrition, by modulating the gut microbiota, orchestrates the early stages of brain development. Drawing insights from animal models and human cohorts, this work underscores the profound implications of maternal gut health for neurodevelopmental trajectories and offers a glimpse into the formulation of targeted interventions able to optimize the health of both mother and offspring. The prospect of tailored dietary recommendations for expectant mothers emerges as a promising and accessible intervention to foster the growth of beneficial gut bacteria, potentially leading to enhanced cognitive outcomes and reduced risks of neurodevelopmental disorders.
摘要：
怀孕是一个以深刻的身体和情感变化为标志的变革期，对母亲和孩子都有深远的影响。新兴的研究表明，母亲在怀孕期间的饮食在影响产前肠道微生物组以及随后塑造后代神经发育方面的关键作用。产妇肠道健康之间错综复杂的相互作用，营养,神经发育结果已经成为发展科学中一个迷人的研究领域。充当母亲和胎儿之间的动态桥梁，母体肠道微生物组，直接和间接,通过不同的途径影响后代的神经发育。这篇全面的综述深入研究了一系列研究，阐明母体营养的推定机制，通过调节肠道微生物群，协调大脑发育的早期阶段。从动物模型和人类队列中汲取见解，这项工作强调了产妇肠道健康对神经发育轨迹的深远影响,并提供了对制定能够优化母亲和后代健康的针对性干预措施的一瞥.为孕妇提供量身定制的饮食建议的前景是一种有希望且可获得的干预措施，以促进有益肠道细菌的生长。可能导致认知结果增强和神经发育障碍风险降低。
