Abstract：
Evidence from clinical and preclinical studies has shown that the cerebellum contributes to cognitive functions, including social behaviors. Now that the cerebellum\'s role in a wider range of behaviors has been confirmed, the question arises whether the cerebellum contributes to social behaviors via the same mechanisms with which it modulates movements. This review seeks to answer whether the cerebellum guides motor and social behaviors through identical pathways. It focuses on studies in which cerebellar cells, synapses, or genes are manipulated in a cell-type specific manner followed by testing of the effects on social and motor behaviors. These studies show that both anatomically restricted and cerebellar cortex-wide manipulations can lead to social impairments without abnormal motor control, and vice versa. These studies suggest that the cerebellum employs different cellular, synaptic, and molecular pathways for social and motor behaviors. Future studies warrant a focus on the diverging mechanisms by which the cerebellum contributes to a wide range of neural functions.
摘要：
临床和临床前研究的证据表明，小脑有助于认知功能，包括社会行为。现在小脑在更广泛的行为中的作用已经得到证实，问题是小脑是否通过调节运动的相同机制对社会行为做出了贡献。这篇评论旨在回答小脑是否通过相同的途径引导运动和社会行为。它专注于小脑细胞的研究，突触，或以细胞类型特定的方式操纵基因，然后测试对社交和运动行为的影响。这些研究表明，在没有异常运动控制的情况下，解剖学限制和小脑皮质范围的操作都可能导致社交障碍，反之亦然。这些研究表明，小脑使用不同的细胞，突触，以及社会和运动行为的分子途径。未来的研究需要关注小脑有助于广泛的神经功能的不同机制。
