Abstract：
In the current study, bioinformatics analysis of the hepatocellular carcinoma (HCC) dataset was conducted with the hepatoprotective effect of the Fuzheng Huayu (FZHY) capsule against the diethylnitrosamine-induced HCC progression analyzed. Eight cell clusters were defined and tanshinone IIA, arachidonic acid, and quercetin, compounds of the FZHY capsule, inhibit HCC progression-related fibrosis by regulating the expression of PLAU and IGFBP3. Combined with the ameliorative effect of the FZHY capsule against liver dysfunctions and expression of PLAU and IGFBP3, our study confirmed the effect of the FZHY capsule on inhibiting the fibrosis-associated HCC progression via regulating the expression of PLAU and IGFBP3.
摘要：
在目前的研究中,对肝细胞癌（HCC）数据集进行生物信息学分析，分析扶正化瘀（FZHY）胶囊对二乙基亚硝胺诱导的HCC进展的肝保护作用。定义了八个细胞簇，丹参酮IIA，花生四烯酸,还有槲皮素,FZHY胶囊的化合物，通过调节PLAU和IGFBP3的表达来抑制HCC进展相关的纤维化。结合FZHY胶囊对肝功能障碍和PLAU和IGFBP3表达的改善作用，我们的研究证实了FZHY胶囊通过调节PLAU和IGFBP3的表达抑制纤维化相关HCC进展的作用。
