Abstract：
Partial heart transplantation is a new approach to deliver growing heart valve implants. Partial heart transplants differ from heart transplants because only the part of the heart containing the necessary heart valve is transplanted. This allows partial heart transplants to grow, similar to the valves in heart transplants. However, the transplant biology of partial heart transplantation remains unexplored. This is a critical barrier to progress of the field. Without knowledge about the specific transplant biology of partial heart transplantation, children with partial heart transplants are empirically treated like children with heart transplants because the valves in heart transplants are known to grow. In order to progress the field, an animal model for partial heart transplantation is necessary. Here, we contribute our surgical protocol for partial heart transplantation in growing piglets. All aspects of partial heart transplantation, including the donor procedure, the recipient procedure, and recipient perioperative care are described in detail. There are important nuances in the conduct of virtually all aspects of open heart surgery that differs in piglets from humans. Our surgical protocol, which is based on our experience with 34 piglets, will allow other investigators to leverage our experience to seek fundamental knowledge about the nature of partial heart transplants. This is significant because the partial heart transplant model in piglets is complex and very resource intensive.
摘要：
部分心脏移植是一种新的方法来提供不断增长的心脏瓣膜植入物。部分心脏移植不同于心脏移植，因为只有含有必要心脏瓣膜的心脏部分被移植。这允许部分心脏移植生长，类似于心脏移植中的瓣膜。然而,部分心脏移植的移植生物学仍未被研究。这是该领域进步的关键障碍。不了解部分心脏移植的特定移植生物学，根据经验，部分心脏移植的儿童被视为心脏移植的儿童，因为已知心脏移植中的瓣膜会生长。为了在这个领域取得进展，部分心脏移植的动物模型是必要的。这里,我们为生长仔猪的部分心脏移植提供了手术方案。部分心脏移植的各个方面，包括捐赠程序,收件人程序，并对受者围手术期护理进行了详细描述。在进行几乎所有方面的心脏直视手术中都存在重要的细微差别，仔猪与人类不同。我们的手术方案,这是根据我们对34只小猪的经验，将允许其他研究人员利用我们的经验来寻求有关部分心脏移植性质的基本知识。这是重要的,因为仔猪中的部分心脏移植模型是复杂的并且非常资源密集。
