PDF(Pubmed)
Abstract：
A 14-year-old male tiger developed anorexia with elevated blood urea nitrogen and creatinine levels. The patient had a palpable abdominal mass and demonstrated neutrophilic leukocytosis and anaemia. Leukocytes, yeast and bacteria were present in the urine. The animal was non-responsive to therapy and was subsequently euthanised. Extensive acute renal papillary necrosis (RPN) with pyelonephritis, chronic nephritis and polycystic renal disease were evident during gross and microscopic pathology examinations. The histologic occurrence of fungal spores and pseudohyphae morphologically consistent with Candida species were observed within the necrotic papillary regions of the kidney and within multiple foci of mild parakeratotic hyperkeratosis present in the gingiva and tongue. Candida albicans along with a slight growth of Escherichia coli were recovered from kidney cultures. Possible contributory factors for the renal candidiasis and associated RPN include predisposing oral candidiasis, polycystic renal disease, ischaemic nephrosclerosis, age-associated or other forms of immunodeficiency and therapy with meloxicam, a non-steroidal anti-inflammatory drug. The absence of apparent lower urinary tract involvement coupled with the presence of intravascular renal \'Candida emboli\' suggest that chronic oral candidiasis was the probable source of the kidney infection.
摘要：
一只14岁的雄性老虎出现厌食症，血液尿素氮和肌酐水平升高。该患者有明显的腹部肿块，并表现出嗜中性白细胞增多和贫血。白细胞,尿液中存在酵母和细菌。该动物对治疗无反应,随后实施安乐死。广泛的急性肾乳头状坏死（RPN）伴肾盂肾炎，在大体和显微镜病理学检查中，慢性肾炎和多囊性肾病明显。在肾脏的坏死乳头状区域以及牙龈和舌头中存在的轻度角化过度角化病变的多个病灶内，观察到真菌孢子和假菌丝的组织学发生在形态上与念珠菌属一致。从肾脏培养物中回收了白色念珠菌以及大肠杆菌的轻微生长。肾念珠菌病和相关RPN的可能促成因素包括易感口腔念珠菌病，多囊性肾病,缺血性肾硬化,与年龄相关或其他形式的免疫缺陷和美洛昔康治疗，一种非甾体抗炎药.没有明显的下尿路受累，再加上血管内肾脏念珠菌栓子的存在，表明慢性口腔念珠菌病是肾脏感染的可能来源。
