PDF(Pubmed)
Abstract：
UNASSIGNED: Observational studies have indicated a possible connection between Helicobacter pylori (H. pylori) infection and eosinophilic esophagitis (EoE), but their causal relationship has yet to be established. To investigate the causal associations between H. pylori infection and EoE, we performed a Mendelian randomization (MR) analysis.
UNASSIGNED: Firstly, we conducted both univariable and multivariable Mendelian randomization (MR) analyses. Furthermore, a two-step MR was carried out to ascertain the potential underlying pathways of these associations, particularly the involvement of inflammatory cytokines. We employed the inverse-variance weighted (IVW) method as the main analysis in our MR study. To enhance the credibility of the results, we also conducted several sensitivity analyses.
UNASSIGNED: Our study demonstrated a noteworthy correlation between genetically predicted anti-H. pylori IgG antibody levels and a reduced risk of EoE (OR=0.325, 95% CI=0.165-0.643, P value=0.004, adj p value=0.009). No significant causal associations were detected between other H. pylori antibodies and EoE in our study. When it comes to multivariable MR analysis controlling for education attainment, household income, and deprivation individually, the independent causal impact of anti-H. pylori IgG on EoE persisted. Surprisingly, the two-step MR analysis indicated that inflammatory factors (IL-4, IL-5, IL-13, IL-17, and IFN-γ) did not appear to mediate the protective effect of H. pylori infection against EoE.
UNASSIGNED: Findings suggested that among the range of H. pylori-related antibodies, anti-H. pylori IgG antibody is the sole causal factor associated with protection against EoE. Certain inflammatory factors may not be involved in mediating this association. These findings make a significant contribution to advancing our understanding of the pathogenesis of EoE and its evolving etiology.
UNASSIGNED: Firstly, we conducted both univariable and multivariable Mendelian randomization (MR) analyses. Furthermore, a two-step MR was carried out to ascertain the potential underlying pathways of these associations, particularly the involvement of inflammatory cytokines. We employed the inverse-variance weighted (IVW) method as the main analysis in our MR study. To enhance the credibility of the results, we also conducted several sensitivity analyses.
UNASSIGNED: Our study demonstrated a noteworthy correlation between genetically predicted anti-H. pylori IgG antibody levels and a reduced risk of EoE (OR=0.325, 95% CI=0.165-0.643, P value=0.004, adj p value=0.009). No significant causal associations were detected between other H. pylori antibodies and EoE in our study. When it comes to multivariable MR analysis controlling for education attainment, household income, and deprivation individually, the independent causal impact of anti-H. pylori IgG on EoE persisted. Surprisingly, the two-step MR analysis indicated that inflammatory factors (IL-4, IL-5, IL-13, IL-17, and IFN-γ) did not appear to mediate the protective effect of H. pylori infection against EoE.
UNASSIGNED: Findings suggested that among the range of H. pylori-related antibodies, anti-H. pylori IgG antibody is the sole causal factor associated with protection against EoE. Certain inflammatory factors may not be involved in mediating this association. These findings make a significant contribution to advancing our understanding of the pathogenesis of EoE and its evolving etiology.
摘要：
■观察性研究表明幽门螺杆菌(H.幽门螺杆菌）感染和嗜酸性粒细胞性食管炎（EoE），但是它们的因果关系尚未确定。为了研究幽门螺杆菌感染与EoE之间的因果关系，我们进行了孟德尔随机化(MR)分析.
■首先，我们进行了单变量和多变量孟德尔随机化(MR)分析.此外，进行了两步MR以确定这些关联的潜在潜在潜在途径，特别是炎性细胞因子的参与。我们采用逆方差加权（IVW）方法作为MR研究的主要分析。提高成果的可信度,我们还进行了一些敏感性分析。
■我们的研究表明，基因预测的抗H.幽门螺杆菌IgG抗体水平和EoE风险降低（OR=0.325，95％CI=0.165-0.643，P值=0.004，adjp值=0.009）。在我们的研究中，其他幽门螺杆菌抗体和EoE之间没有检测到显著的因果关系。当涉及到多变量MR分析控制教育程度时，家庭收入,单独剥夺，抗H的独立因果影响EoE上的幽门螺杆菌IgG持续存在。令人惊讶的是,两步MR分析表明,炎症因子(IL-4,IL-5,IL-13,IL-17和IFN-γ)似乎并未介导幽门螺杆菌感染对EoE的保护作用.
■研究结果表明，在幽门螺杆菌相关抗体的范围中，抗H.幽门螺杆菌IgG抗体是与针对EoE的保护相关的唯一致病因素。某些炎症因子可能不参与介导这种关联。这些发现为促进我们对EoE的发病机理及其不断发展的病因的理解做出了重要贡献。
■首先，我们进行了单变量和多变量孟德尔随机化(MR)分析.此外，进行了两步MR以确定这些关联的潜在潜在潜在途径，特别是炎性细胞因子的参与。我们采用逆方差加权（IVW）方法作为MR研究的主要分析。提高成果的可信度,我们还进行了一些敏感性分析。
■我们的研究表明，基因预测的抗H.幽门螺杆菌IgG抗体水平和EoE风险降低（OR=0.325，95％CI=0.165-0.643，P值=0.004，adjp值=0.009）。在我们的研究中，其他幽门螺杆菌抗体和EoE之间没有检测到显著的因果关系。当涉及到多变量MR分析控制教育程度时，家庭收入,单独剥夺，抗H的独立因果影响EoE上的幽门螺杆菌IgG持续存在。令人惊讶的是,两步MR分析表明,炎症因子(IL-4,IL-5,IL-13,IL-17和IFN-γ)似乎并未介导幽门螺杆菌感染对EoE的保护作用.
■研究结果表明，在幽门螺杆菌相关抗体的范围中，抗H.幽门螺杆菌IgG抗体是与针对EoE的保护相关的唯一致病因素。某些炎症因子可能不参与介导这种关联。这些发现为促进我们对EoE的发病机理及其不断发展的病因的理解做出了重要贡献。
