PDF(Pubmed)
Abstract：
Lactic acid was formerly regarded as a byproduct of metabolism. However, extensive investigations into the intricacies of cancer development have revealed its significant contributions to tumor growth, migration, and invasion. Post-translational modifications involving lactate have been widely observed in histone and non-histone proteins, and these modifications play a crucial role in regulating gene expression by covalently attaching lactoyl groups to lysine residues in proteins. This discovery has greatly enhanced our comprehension of lactic acid\'s involvement in disease pathogenesis. In this article, we provide a comprehensive review of the intricate relationship between lactate and tumor immunity, the occurrence of lactylation in malignant tumors, and the exploitation of targeted lactate-lactylation in tumor immunotherapy. Additionally, we discuss future research directions, aiming to offer novel insights that could inform the investigation, diagnosis, and treatment of related diseases.
摘要：
乳酸以前被认为是代谢的副产品。然而,对癌症发展的复杂性的广泛研究揭示了它对肿瘤生长的重要贡献，迁移,和入侵。在组蛋白和非组蛋白蛋白中广泛观察到涉及乳酸的翻译后修饰，这些修饰通过共价连接乳酰和蛋白质中的赖氨酸残基在调节基因表达中起着至关重要的作用。这一发现大大增强了我们对乳酸参与疾病发病机制的理解。在这篇文章中,我们对乳酸与肿瘤免疫之间的复杂关系进行了全面的综述，在恶性肿瘤中发生乳酸化，以及在肿瘤免疫治疗中靶向乳酸-乳酸化的开发。此外,我们讨论了未来的研究方向，旨在提供新颖的见解，可以为调查提供信息，诊断,以及相关疾病的治疗。
