PDF(Pubmed)
Abstract：
The Avon Longitudinal Study of Parents and Children (ALSPAC) is a prospective population-based cohort study which recruited pregnant women in 1990-1992 and has followed these women, their partners (Generation 0; G0) and their offspring (Generation 1; G1) ever since. The study reacted rapidly to the coronavirus disease 2019 (COVID-19) pandemic, deploying three online questionnaires in March, May and October 2020. Home-based antibody tests accompanied the third questionnaire. In addition, linkage to Public Health England (PHE) Pillar I and II testing results has been obtained for all participants who have consented or for whom we have NHS Confidentiality approval group permitted Section 251 access. For the purposes of ongoing study, we have identified likely cases of COVID-19 from available data. To determine likely cases, we have developed a hierarchy depending on the source of the data: self-report, antibody test result and Pillar I and II linkage and a combination thereof; providing more certainty in the case status. This data note describes how we have ascertained case status in ALSPAC. The subsequent case variable will be made available through our COVID release files alongside testing data from PHE.
摘要：
雅芳父母和子女纵向研究（ALSPAC）是一项基于人群的前瞻性队列研究，该研究在1990-1992年招募了孕妇，并跟踪了这些妇女，从那时起，他们的伴侣(第0代；G0代)和他们的后代(第1代；G1代)。这项研究对2019年冠状病毒病(COVID-19)大流行反应迅速，3月份部署了三份在线问卷，2020年5月和10月。基于家庭的抗体测试伴随着第三份问卷。此外,与英国公共卫生(PHE)支柱I和II的联系已经获得了所有同意的参与者或我们有NHS保密批准小组允许进入第251节的参与者的测试结果.为了进行研究，我们从现有数据中确定了可能的COVID-19病例。为了确定可能的情况，我们根据数据的来源制定了一个层次结构：自我报告，抗体测试结果和支柱I和II连接及其组合；提供病例状态的更多确定性。本数据说明描述了我们如何在ALSPAC中确定病例状态。随后的病例变量将通过我们的COVID发布文件以及PHE的测试数据提供。
