PDF(Pubmed)
Abstract：
UNASSIGNED: Cardiovascular diseases (CVDs) are the leading causes of global mortality and disability. Several studies demonstrated that metabolic risk factors increase cardiovascular mortality. The aim of this study is to examine CVDs deaths and population attributable fractions (PAFs) of their metabolic risk factors in Iran.
UNASSIGNED: This is a study on 8621 participants aged 45-75 years and older, recruited in the repeated measurement phase of the Golestan cohort study (GCS) in northeast of Iran. The Cox proportional hazards model was used to determine the adjusted hazard ratios (HRs). PAFs were calculated to enumerate CVDs mortality avoidable in the population if metabolic risk factors were eliminated.
UNASSIGNED: The mortality of CVDs was attributable to metabolic factors, including high waist circumference (PAF, 28 %, [95 % CI: 16%-38 %]), high fasting blood sugar (FBS) (20 %, [15%-24 %]), overweight and obesity (19 %, [8%-28 %]), high blood pressure (16 %, [11%-21 %]), high low-density lipoprotein cholesterol (LDL-C) (8 %, [1%-15 %]), and high triglyceride (TG) (7 %, [3%-11 %]). Collectively, these metabolic risk factors accounted for 50 % of CVDs deaths. Females (67 %, [50%-78 %]) had a higher joint PAF of metabolic risk factors compared to males (43 %, [27%-55 %]).
UNASSIGNED: The pattern of CVDs mortality attributable to metabolic risk factors in this study is not the same as similar studies in other parts of the world and previous studies in Iran. It is imperative that CVDs risk factors be specifically evaluated and addressed in various populations due to variety in geographical and temporal patterns in contribution of metabolic risk factors to CVD mortality.
UNASSIGNED: This is a study on 8621 participants aged 45-75 years and older, recruited in the repeated measurement phase of the Golestan cohort study (GCS) in northeast of Iran. The Cox proportional hazards model was used to determine the adjusted hazard ratios (HRs). PAFs were calculated to enumerate CVDs mortality avoidable in the population if metabolic risk factors were eliminated.
UNASSIGNED: The mortality of CVDs was attributable to metabolic factors, including high waist circumference (PAF, 28 %, [95 % CI: 16%-38 %]), high fasting blood sugar (FBS) (20 %, [15%-24 %]), overweight and obesity (19 %, [8%-28 %]), high blood pressure (16 %, [11%-21 %]), high low-density lipoprotein cholesterol (LDL-C) (8 %, [1%-15 %]), and high triglyceride (TG) (7 %, [3%-11 %]). Collectively, these metabolic risk factors accounted for 50 % of CVDs deaths. Females (67 %, [50%-78 %]) had a higher joint PAF of metabolic risk factors compared to males (43 %, [27%-55 %]).
UNASSIGNED: The pattern of CVDs mortality attributable to metabolic risk factors in this study is not the same as similar studies in other parts of the world and previous studies in Iran. It is imperative that CVDs risk factors be specifically evaluated and addressed in various populations due to variety in geographical and temporal patterns in contribution of metabolic risk factors to CVD mortality.
摘要：
心血管疾病(CVDs)是全球死亡和残疾的主要原因。多项研究表明，代谢危险因素会增加心血管死亡率。这项研究的目的是研究伊朗的CVD死亡和其代谢风险因素的人口归因分数（PAF）。
■这是一项针对8621名45-75岁及以上参与者的研究，在伊朗东北部的Golestan队列研究（GCS）的重复测量阶段招募。Cox比例风险模型用于确定调整后的风险比(HR)。如果消除了代谢危险因素，则计算PAF以列举人群中可避免的CVD死亡率。
■心血管疾病的死亡率可归因于代谢因素，包括高腰围(PAF，28%,[95%CI：16%-38%])，高空腹血糖（FBS）（20％，[15%-24%])，超重和肥胖(19%，[8%-28%])，高血压（16%，[11%-21%])，高低密度脂蛋白胆固醇（LDL-C）（8％，[1%-15%])，和高甘油三酯(TG)(7%，[3%-11%]）。总的来说，这些代谢危险因素占CVD死亡的50%.女性（67%，[50％-78％]）与男性相比，代谢危险因素的联合PAF更高（43％，[27%-55%]）。
■在这项研究中，归因于代谢危险因素的CVD死亡率的模式与世界其他地区的类似研究以及伊朗的先前研究并不相同。由于代谢危险因素对CVD死亡率的贡献的地理和时间模式的多样性，因此必须在各种人群中专门评估和解决CVD危险因素。
■这是一项针对8621名45-75岁及以上参与者的研究，在伊朗东北部的Golestan队列研究（GCS）的重复测量阶段招募。Cox比例风险模型用于确定调整后的风险比(HR)。如果消除了代谢危险因素，则计算PAF以列举人群中可避免的CVD死亡率。
■心血管疾病的死亡率可归因于代谢因素，包括高腰围(PAF，28%,[95%CI：16%-38%])，高空腹血糖（FBS）（20％，[15%-24%])，超重和肥胖(19%，[8%-28%])，高血压（16%，[11%-21%])，高低密度脂蛋白胆固醇（LDL-C）（8％，[1%-15%])，和高甘油三酯(TG)(7%，[3%-11%]）。总的来说，这些代谢危险因素占CVD死亡的50%.女性（67%，[50％-78％]）与男性相比，代谢危险因素的联合PAF更高（43％，[27%-55%]）。
■在这项研究中，归因于代谢危险因素的CVD死亡率的模式与世界其他地区的类似研究以及伊朗的先前研究并不相同。由于代谢危险因素对CVD死亡率的贡献的地理和时间模式的多样性，因此必须在各种人群中专门评估和解决CVD危险因素。
