PDF(Pubmed)
Abstract：
UNASSIGNED: The ability of a quality of life (QoL) to guide balloon pulmonary angioplasty (BPA) among patients with inoperable chronic thromboembolic pulmonary hypertension (CTEPH) has not been fully investigated. This study explored the relationship between QoL scores and hemodynamics in CTEPH patients after BPA and examined whether QoL could be applied as a treatment endpoint.
UNASSIGNED: This cohort study included patients with inoperable CTEPH who had undergone at least four sessions of BPA. The patients\' demographic and clinical data as well as hemodynamic parameters and scores from the RAND 36-item short-form QoL questionnaire were recorded and compared before and after BPA.
UNASSIGNED: After BPA treatments, clinical characteristics, hemodynamic parameters, as well as QoL score improved significantly. A physical component summary (PCS) score of 35 or 46 can be used as the cutoff value for predicting better World Health Organization functional classification (WHO FC). Patients who had a higher PCS would have longer 6-min walk distance (6MWD), lower pulmonary vascular resistance (PVR), and better cardiac output (CO) both before and after BPA. However, 19 patients (55.9%) with a higher PCS score after BPA did not achieve the goal of mean pulmonary arterial pressure (mPAP) ≤30 mmHg. During the follow-up period, a significant reduction of PVR was observed, but the PCS score improved a little.
UNASSIGNED: QoL is a useful tool for assessing the exercise endurance of patients with inoperable CTEPH treated with BPA, but is insufficient to serve as a treatment endpoint for BPA.
UNASSIGNED: This cohort study included patients with inoperable CTEPH who had undergone at least four sessions of BPA. The patients\' demographic and clinical data as well as hemodynamic parameters and scores from the RAND 36-item short-form QoL questionnaire were recorded and compared before and after BPA.
UNASSIGNED: After BPA treatments, clinical characteristics, hemodynamic parameters, as well as QoL score improved significantly. A physical component summary (PCS) score of 35 or 46 can be used as the cutoff value for predicting better World Health Organization functional classification (WHO FC). Patients who had a higher PCS would have longer 6-min walk distance (6MWD), lower pulmonary vascular resistance (PVR), and better cardiac output (CO) both before and after BPA. However, 19 patients (55.9%) with a higher PCS score after BPA did not achieve the goal of mean pulmonary arterial pressure (mPAP) ≤30 mmHg. During the follow-up period, a significant reduction of PVR was observed, but the PCS score improved a little.
UNASSIGNED: QoL is a useful tool for assessing the exercise endurance of patients with inoperable CTEPH treated with BPA, but is insufficient to serve as a treatment endpoint for BPA.
摘要：
■在无法手术的慢性血栓栓塞性肺动脉高压（CTEPH）患者中，生活质量（QoL）指导球囊肺血管成形术（BPA）的能力尚未得到充分研究。这项研究探讨了BPA后CTEPH患者的QoL评分与血流动力学之间的关系，并检查了QoL是否可以用作治疗终点。
■这项队列研究纳入了不能手术的CTEPH患者，这些患者接受了至少四次BPA治疗。记录并比较BPA前后患者的人口统计学和临床数据以及来自RAND36项简短QoL问卷的血流动力学参数和评分。
■BPA处理后，临床特征,血液动力学参数,以及QoL评分明显改善。35或46的物理成分汇总（PCS）评分可用作预测更好的世界卫生组织功能分类（WHOFC）的截止值。患者有较高的PCS将有更长的6分钟步行距离（6MWD），降低肺血管阻力（PVR），和更好的心输出量（CO）之前和之后的BPA。然而,BPA后PCS评分较高的19例患者（55.9％）未达到平均肺动脉压（mPAP）≤30mmHg的目标。在后续期间,观察到PVR显着降低，但是PCS分数提高了一点。
■QoL是评估BPA治疗无法手术的CTEPH患者运动耐力的有用工具，但不足以作为BPA的治疗终点。
■这项队列研究纳入了不能手术的CTEPH患者，这些患者接受了至少四次BPA治疗。记录并比较BPA前后患者的人口统计学和临床数据以及来自RAND36项简短QoL问卷的血流动力学参数和评分。
■BPA处理后，临床特征,血液动力学参数,以及QoL评分明显改善。35或46的物理成分汇总（PCS）评分可用作预测更好的世界卫生组织功能分类（WHOFC）的截止值。患者有较高的PCS将有更长的6分钟步行距离（6MWD），降低肺血管阻力（PVR），和更好的心输出量（CO）之前和之后的BPA。然而,BPA后PCS评分较高的19例患者（55.9％）未达到平均肺动脉压（mPAP）≤30mmHg的目标。在后续期间,观察到PVR显着降低，但是PCS分数提高了一点。
■QoL是评估BPA治疗无法手术的CTEPH患者运动耐力的有用工具，但不足以作为BPA的治疗终点。
