PDF(Pubmed)
Abstract：
UNASSIGNED: Ectopic pregnancy is a crucial problem in Gynaecology. Previous studies concerning the medical treatment of ectopic pregnancies, have used only β-hCG (beta- human chorionic gonadotropin) values, to monitor the successful response to treatment. The current study was a PhD (Doctorate of Philosophy) thesis research, which has evaluated the vascularity indices\' changes. The values of vascularity indices could be used, in combination with β-hCG values and the gestational sac dimensions, in every medically treated ectopic pregnancy. The results could be used, for monitoring the course of all medically treated ectopic pregnancies.
UNASSIGNED: 72 women of reproductive age have taken part in the study. They have been admitted due to secondary amenorrhea, positive β-hCG test, with or without vaginal bleeding. The participants took part voluntarily and were allocated in two groups. The first group consisted of 37 women, who were possible normal or threatened intrauterine pregnancies (control group). The second group consisted of 35 women, whose sonographic findings suggested ectopic pregnancy, and qualified for methotrexate treatment (study group). Sonographic control and measurement of the vascularity indices (PI - RI) (Pulsatility index - Resistance index) of the ectopic pregnancy was conducted, in combination with β-hCG values for every admitted or outpatient woman.The dimensions of the gestational sac of both groups were measured during four consecutive periods of time. The control group has shown progressively increasing sac dimensions, whereas, in the study group sac dimensions were more stable or growing gradually smaller. The exception where those ectopic pregnancies that ruptured, which have also shown a gradual enlargement of the sac.
UNASSIGNED: The endometrial thickness of the study group was gradually decreasing up to 76 % per day, and the more eminent, but not statistically significant decrease, was observed in the single dose regiment of methotrexate. Moreover, the quantitative PI and RI were evaluated, and the main finding was that there were no statistically significant decreases in any of the two groups. Concerning the study group, methotrexate treatment was successful, since there was a decrease of up to 80 %, whereas a clearly significant correlation was found between the β-hCG levels and the RI.
UNASSIGNED: The vascularity indices could be used safely, in combination with β-hCG levels and the decrease of the gestational sac dimensions, as criteria for the evaluation of response to medical treatment of ectopic pregnancies.
UNASSIGNED: 72 women of reproductive age have taken part in the study. They have been admitted due to secondary amenorrhea, positive β-hCG test, with or without vaginal bleeding. The participants took part voluntarily and were allocated in two groups. The first group consisted of 37 women, who were possible normal or threatened intrauterine pregnancies (control group). The second group consisted of 35 women, whose sonographic findings suggested ectopic pregnancy, and qualified for methotrexate treatment (study group). Sonographic control and measurement of the vascularity indices (PI - RI) (Pulsatility index - Resistance index) of the ectopic pregnancy was conducted, in combination with β-hCG values for every admitted or outpatient woman.The dimensions of the gestational sac of both groups were measured during four consecutive periods of time. The control group has shown progressively increasing sac dimensions, whereas, in the study group sac dimensions were more stable or growing gradually smaller. The exception where those ectopic pregnancies that ruptured, which have also shown a gradual enlargement of the sac.
UNASSIGNED: The endometrial thickness of the study group was gradually decreasing up to 76 % per day, and the more eminent, but not statistically significant decrease, was observed in the single dose regiment of methotrexate. Moreover, the quantitative PI and RI were evaluated, and the main finding was that there were no statistically significant decreases in any of the two groups. Concerning the study group, methotrexate treatment was successful, since there was a decrease of up to 80 %, whereas a clearly significant correlation was found between the β-hCG levels and the RI.
UNASSIGNED: The vascularity indices could be used safely, in combination with β-hCG levels and the decrease of the gestational sac dimensions, as criteria for the evaluation of response to medical treatment of ectopic pregnancies.
摘要：
■异位妊娠是妇科的一个关键问题。以前关于异位妊娠药物治疗的研究，仅使用β-hCG（β-人绒毛膜促性腺激素）值，监测治疗的成功反应。目前的研究是博士（哲学博士）论文研究，它评估了血管分布指数的变化。可以使用血管分布指数的值，结合β-hCG值和孕囊尺寸，在每次药物治疗的异位妊娠中。结果可以使用，用于监测所有药物治疗的异位妊娠的过程。
■72名育龄妇女参加了这项研究。他们因继发性闭经入院,β-hCG试验阳性,有或没有阴道出血。参与者自愿参加，分为两组。第一组由37名女性组成，可能是正常或先兆宫内妊娠（对照组）。第二组由35名女性组成，超声检查结果提示异位妊娠,符合甲氨蝶呤治疗资格（研究组）。超声控制和测量异位妊娠的血管指数（PI-RI）（搏动指数-阻力指数），结合每位入院或门诊女性的β-hCG值。在连续四个时间段内测量两组的孕囊尺寸。对照组显示出逐渐增加的囊尺寸，然而,在研究组中，囊尺寸更稳定或逐渐变小。那些破裂的异位妊娠的例外，这也显示了囊的逐渐扩大。
■研究组的子宫内膜厚度逐渐减少，每天高达76%，越杰出，但没有统计上显著的下降，在甲氨蝶呤的单剂量方案中观察到。此外，定量PI和RI进行了评估，主要发现是两组均无统计学显著下降.关于研究小组，甲氨蝶呤治疗成功,因为下降了80%，而β-hCG水平与RI之间存在明显的相关性。
■血管分布指数可以安全使用，结合β-hCG水平和孕囊尺寸的减少，作为评估异位妊娠药物治疗反应的标准。
■72名育龄妇女参加了这项研究。他们因继发性闭经入院,β-hCG试验阳性,有或没有阴道出血。参与者自愿参加，分为两组。第一组由37名女性组成，可能是正常或先兆宫内妊娠（对照组）。第二组由35名女性组成，超声检查结果提示异位妊娠,符合甲氨蝶呤治疗资格（研究组）。超声控制和测量异位妊娠的血管指数（PI-RI）（搏动指数-阻力指数），结合每位入院或门诊女性的β-hCG值。在连续四个时间段内测量两组的孕囊尺寸。对照组显示出逐渐增加的囊尺寸，然而,在研究组中，囊尺寸更稳定或逐渐变小。那些破裂的异位妊娠的例外，这也显示了囊的逐渐扩大。
■研究组的子宫内膜厚度逐渐减少，每天高达76%，越杰出，但没有统计上显著的下降，在甲氨蝶呤的单剂量方案中观察到。此外，定量PI和RI进行了评估，主要发现是两组均无统计学显著下降.关于研究小组，甲氨蝶呤治疗成功,因为下降了80%，而β-hCG水平与RI之间存在明显的相关性。
■血管分布指数可以安全使用，结合β-hCG水平和孕囊尺寸的减少，作为评估异位妊娠药物治疗反应的标准。
