Abstract:
The expression of E-cadherin on Langerhans cells (LC) is required for adequate dendrite intercalation between epidermal keratinocytes. Upon disruption of epidermal homeostasis by tape stripping, E-cadherin competent LC extend dendrites reaching up to the epidermal surface, while E-cad deficient LC lack this ability.
摘要:
E-cadherin在朗格汉斯细胞(LC)上的表达是表皮角质形成细胞之间充分的树突插入所必需的。通过胶带剥离破坏表皮稳态后,E-cadherin主管LC将树突延伸到表皮表面,而缺乏电子CAD的LC缺乏这种能力。