METHODS: We searched PubMed, Web of Science and Embase, using retrieval type like (\"Neurogenic Lower Urinary Tract Dysfunction\" OR \"Spinal cord injury\" OR \"Spinal Cord Trauma\") AND (\"bladder cancer\" OR \"bladder neoplasm\" OR \"bladder carcinoma\" OR \"Urinary Bladder Neoplasms\" OR \"Bladder Tumor\"). In Web of Science, the retrieval type was searched as \"Topic\", and in PubMed and Embase, as \"All Field\". The methodological quality of eligible studies and their risk of bias were assessed using the Newcastle-Ottawa scale. This article is registered in PROSPERO with the CBD number: CRD42024508514.
RESULTS: In WOS, we searched 219 related papers, in PubMed, 122 and in Embase, 363. Thus, a total of 254 articles were included after passing the screening, within a time range between 1960 and 2023. A comprehensive analysis of the data showed that the mortality and incidence rates of bladder cancer in spinal cord injury patients were higher than that of the general population, and the most frequent pathological type was squamous cell carcinoma. In parallel to long-term urinary tract infection and indwelling catheterization, the role of molecules such as NO, MiR 1949 and Rb 1. was found to be crucial pathogenetically.
CONCLUSIONS: This review highlights the risk of bladder cancer in SCI patients, comprehensively addressing the clinical characteristics and related molecular mechanisms. However, given that there are few studies on the molecular mechanisms of bladder cancer in spinal cord injury, further research is needed to expand the understanding of the disease.
方法:我们搜索了PubMed,WebofScience和Embase,使用检索类型,如(\"神经源性下尿路功能障碍\"或\"脊髓损伤\"或\"脊髓创伤\")和(\"膀胱癌\"或\"膀胱肿瘤\"或\"膀胱癌\"或\"膀胱肿瘤\"或\"膀胱肿瘤\")。在WebofScience中,检索类型搜索为\"Topic\",在PubMed和Embase中,作为“所有字段”。使用纽卡斯尔-渥太华量表评估合格研究的方法学质量及其偏倚风险。本文在PROSPERO中注册,CBD编号:CRD42024508514。
结果:在WOS中,我们搜索了219篇相关论文,在PubMed中,122和Embase,363.因此,通过筛选后,共纳入254篇文章,在1960年至2023年之间的时间范围内。数据综合分析显示,脊髓损伤患者膀胱癌的死亡率和发病率均高于一般人群,最常见的病理类型是鳞状细胞癌。在长期尿路感染和留置导尿的同时,分子如NO的作用,MiR1949和Rb1。被发现在致病方面至关重要。
结论:这篇综述强调了SCI患者患膀胱癌的风险,全面解决临床特征和相关分子机制。然而,鉴于关于膀胱癌在脊髓损伤中的分子机制的研究很少,需要进一步的研究来扩大对这种疾病的认识。