PDF(Pubmed)
Abstract：
Clinical application of cardiac magnetic resonance (CMR) is expanding but CMR assessment of LV diastolic function is still being validated. The purpose of this study was to validate assessments of left ventricular (LV) diastolic dysfunction (DD) using CMR by comparing with transthoracic echocardiography (TTE) performed on the same day. Patients with suspected or diagnosed cardiomyopathy (n = 63) and healthy volunteers (n = 24) were prospectively recruited and included in the study. CMR diastolic parameters were measured on cine images and velocity-encoded phase contrast cine images and compared with corresponding parameters measured on TTE. A contextual correlation feature tracking method was developed to calculate the mitral annular velocity curve. LV DD was classified by CMR and TTE following 2016 guidelines. Overall DD classification was 78.1% concordant between CMR and TTE (p < 0.0001). The trans-mitral inflow parameters correlated well between the two modalities (E, r = 0.78; A, r = 0.90; E/A, r = 0.82; all p < 0.0001) while the remaining diastolic parameters showed moderate correlation (e\', r = 0.64; E/e\', r = 0.54; left atrial volume index (LAVi), r = 0.61; all p < 0.0001). Classification of LV diastolic function by CMR showed good concordance with standardized grades established for TTE. CMR-based LV diastolic function may be integrated in routine clinical practice.Name of the registry: Technical Development of Cardiovascular Magnetic Resonance Imaging. Trial registration number: NCT00027170. Date of registration: November 26, 2001. URL of trial registry record: https://clinicaltrials.gov/ct2/show/NCT00027170.
摘要：
心脏磁共振（CMR）的临床应用正在扩大，但CMR对LV舒张功能的评估仍在验证中。这项研究的目的是通过与同一天进行的经胸超声心动图（TTE）进行比较，验证使用CMR对左心室（LV）舒张功能障碍（DD）的评估。前瞻性招募疑似或诊断为心肌病的患者（n=63）和健康志愿者（n=24）并纳入研究。在电影图像和速度编码的相位对比电影图像上测量CMR舒张参数，并将其与在TTE上测量的相应参数进行比较。开发了一种上下文相关特征跟踪方法来计算二尖瓣环速度曲线。根据2016年指南，CMR和TTE对LVDD进行了分类。总体DD分类在CMR和TTE之间的一致性为78.1%(p<0.0001)。两种模式之间的经二尖瓣流入参数相关性良好（E，r=0.78；A，r=0.90；E/A，r=0.82；所有p<0.0001），而其余舒张参数显示中等相关性（e'，r=0.64；E/e\'，r=0.54;左心房容积指数(LAVi),r=0.61；所有p<0.0001）。CMR对LV舒张功能的分类与TTE建立的标准化等级具有良好的一致性。基于CMR的LV舒张功能可以在常规临床实践中整合。注册名称：心血管磁共振成像技术发展。试用注册号：NCT00027170。注册日期：2001年11月26日。试验注册记录的URL：https://clinicaltrials.gov/ct2/show/NCT00027170。
