Abstract：
The OPG/RANKL/RANK framework, along with its specific receptors, plays a crucial role in bone remodeling and the functioning of the central nervous system (CNS) and associated disorders. Recent research and investigations provide evidence that the components of osteoprotegerin (OPG), receptor activator of NF-kB ligand (RANKL), and receptor activator of NF-kB (RANK) are expressed in the CNS. The CNS structure encompasses cells involved in neuroinflammation, including local macrophages, inflammatory cells, and microglia that cross the blood-brain barrier. The OPG/RANKL/RANK trio modulates the neuroinflammatory response based on the molecular context. The levels of OPG/RANKL/RANK components can serve as biomarkers in the blood and cerebrospinal fluid. They act as neuroprotectants following brain injuries and also participate in the regulation of body weight, internal body temperature, brain ischemia, autoimmune encephalopathy, and energy metabolism. Although the OPG/RANKL/RANK system is primarily known for its role in bone remodeling, further exploring deeper into its multifunctional nature can uncover new functions and novel drug targets for diseases not previously associated with OPG/RANKL/RANK signaling.
摘要：
OPG/RANKL/RANK框架，以及它的特定受体，在骨重建和中枢神经系统（CNS）的功能以及相关疾病中起着至关重要的作用。最近的研究和调查提供了证据，骨保护素（OPG）的成分，NF-kB受体激活剂配体（RANKL），NF-kB的受体激活剂(RANK)在CNS中表达。CNS结构包括参与神经炎症的细胞，包括局部巨噬细胞,炎症细胞，和穿过血脑屏障的小胶质细胞。OPG/RANKL/RANK三重奏基于分子背景调节神经炎症反应。OPG/RANKL/RANK组分的水平可以作为血液和脑脊液中的生物标志物。它们在脑损伤后充当神经保护剂，并参与体重的调节，体内温度,脑缺血,自身免疫性脑病,和能量代谢。尽管OPG/RANKL/RANK系统主要以其在骨重建中的作用而闻名，进一步深入探索其多功能性质,可以发现以前与OPG/RANKL/RANK信号传导无关的疾病的新功能和新的药物靶点.
