Abstract：
Skin tissue engineering (STE) is widely regarded as an effective approach for skin regeneration. Several synthetic biomaterials utilized for STE have demonstrated favorable fibrillar characteristics, facilitating the regeneration of skin tissue at the site of injury, yet they have exhibited a lack of in situ degradation. Various types of skin regenerative materials, such as hydrogels, nanofiber scaffolds, and 3D-printing composite scaffolds, have recently emerged for use in STE. Electrospun nanofiber scaffolds possess distinct advantages, such as their wide availability, similarity to natural structures, and notable tissue regenerative capabilities, which have garnered the attention of researchers. Hence, electrospun nanofiber scaffolds may serve as innovative biological materials possessing the necessary characteristics and potential for use in tissue engineering. Recent research has demonstrated the potential of electrospun nanofiber scaffolds to facilitate regeneration of skin tissues. Nevertheless, there is a need to enhance the rapid degradation and limited mechanical properties of electrospun nanofiber scaffolds in order to strengthen their effectiveness in soft tissue engineering applications in clinical settings. This Review centers on advanced research into electrospun nanofiber scaffolds, encompassing preparation methods, materials, fundamental research, and preclinical applications in the field of science, technology, and engineering. The existing challenges and prospects of electrospun nanofiber scaffolds in STE are also addressed.
摘要：
皮肤组织工程（STE）被广泛认为是皮肤再生的有效方法。用于STE的几种合成生物材料已显示出良好的原纤维特性，促进损伤部位皮肤组织的再生，然而，他们表现出缺乏原位降解。各种类型的皮肤再生材料，如水凝胶，纳米纤维支架，和3D打印复合支架，最近出现用于STE。静电纺纳米纤维支架具有独特的优势，例如它们的广泛可用性，与自然结构相似，和显著的组织再生能力，这引起了研究人员的注意。因此，静电纺纳米纤维支架可以作为创新的生物材料，具有必要的特性和潜力，用于组织工程。最近的研究已经证明了电纺纳米纤维支架促进皮肤组织再生的潜力。然而，有必要提高静电纺纳米纤维支架的快速降解和有限的机械性能，以加强其在临床软组织工程应用中的有效性。这篇综述集中在电纺纳米纤维支架的先进研究，包括制备方法，材料,基础研究,以及在科学领域的临床前应用，技术,和工程。还解决了静电纺纳米纤维支架在STE中的现有挑战和前景。
