Abstract：
OBJECTIVE: Can women with partial 17α-hydroxylase deficiency (17-OHD) conceive naturally with adequate hormonal control and endometrial preparation?
METHODS: This report presents two cases of women with partial 17-OHD who achieved successful pregnancies. The first case involved a 27-year-old Chinese woman with recurrent cysts and infertility, and the second case involved a 32-year-old Chinese woman with a complex disorder requiring IVF. Both cases were treated with oral prednisone to control hormone concentrations and underwent endometrial preparation.
RESULTS: In the first case, the patient resumed spontaneous ovulation, conceived naturally, and gave birth to a healthy baby. In the second case, after cryopreserving embryos due to a thin endometrium, the patient underwent frozen embryo transfer and achieved a singleton pregnancy.
CONCLUSIONS: This study suggests that women with partial 17-OHD can conceive naturally with appropriate hormonal management and endometrial preparation. These findings provide valuable insights into the reproductive potential of women with this disorder, and highlight the importance of further research in this area.
METHODS: This report presents two cases of women with partial 17-OHD who achieved successful pregnancies. The first case involved a 27-year-old Chinese woman with recurrent cysts and infertility, and the second case involved a 32-year-old Chinese woman with a complex disorder requiring IVF. Both cases were treated with oral prednisone to control hormone concentrations and underwent endometrial preparation.
RESULTS: In the first case, the patient resumed spontaneous ovulation, conceived naturally, and gave birth to a healthy baby. In the second case, after cryopreserving embryos due to a thin endometrium, the patient underwent frozen embryo transfer and achieved a singleton pregnancy.
CONCLUSIONS: This study suggests that women with partial 17-OHD can conceive naturally with appropriate hormonal management and endometrial preparation. These findings provide valuable insights into the reproductive potential of women with this disorder, and highlight the importance of further research in this area.
摘要：
目的：部分17α-羟化酶缺乏症（17-OHD）的女性是否可以通过适当的激素控制和子宫内膜准备自然怀孕？
方法：本报告介绍了两例成功怀孕的部分17-OHD女性。首例病例涉及一名27岁的中国女性，患有复发性囊肿和不孕症，第二例涉及一名32岁的中国女性，患有复杂疾病，需要IVF。两例均口服泼尼松控制激素浓度，并进行子宫内膜准备。
结果：在第一种情况下，患者恢复了自发排卵，自然构思，生下了一个健康的宝宝.在第二种情况下，由于子宫内膜薄而冷冻保存胚胎后，患者接受了冷冻胚胎移植，并实现了单胎妊娠。
结论：这项研究表明，17-OHD患者可以通过适当的激素管理和子宫内膜准备自然受孕。这些发现为患有这种疾病的女性的生殖潜力提供了有价值的见解，并强调了在这一领域进一步研究的重要性。
方法：本报告介绍了两例成功怀孕的部分17-OHD女性。首例病例涉及一名27岁的中国女性，患有复发性囊肿和不孕症，第二例涉及一名32岁的中国女性，患有复杂疾病，需要IVF。两例均口服泼尼松控制激素浓度，并进行子宫内膜准备。
结果：在第一种情况下，患者恢复了自发排卵，自然构思，生下了一个健康的宝宝.在第二种情况下，由于子宫内膜薄而冷冻保存胚胎后，患者接受了冷冻胚胎移植，并实现了单胎妊娠。
结论：这项研究表明，17-OHD患者可以通过适当的激素管理和子宫内膜准备自然受孕。这些发现为患有这种疾病的女性的生殖潜力提供了有价值的见解，并强调了在这一领域进一步研究的重要性。
