Vivrovaire was a French multicenter cohort of patients with EOC free of disease 3 years after CT completion. Persistent CIPN was assessed using the FACT/GOG-Ntx4 self-questionnaire. The association of homozygous (hom) or heterozygous (het) single nucleotide polymorphisms (SNPs) in selected genes was evaluated.
130 patients were included with a median time from CT completion of 63 [35-180] months. The median CIPN score was 37 [18-44], with 35 (26.9%) patients reporting severe CIPN (<33). SNPs were identified as follows: CYP2C8 [hom, n = 32 (24.6%)/het, n = 99, (76.2%)]; CYP3A4 [hom, n = 0 (0%)/het, n = 8 (6.2%)], ERCC1 [hom, n = 21 (16.2%)/het, n = 57 (43.8%)], and XPC [hom, n = 45 (34.6%)/het, n = 66 (50.8%)]. In univariate analysis, the identification of ≥1 hom SNP was associated with a lower CIPN score (continuous variable; p = 0.045). Patients harboring hom or het CYP2C8_rs1934951 SNP reported more likely severe CIPN (threshold <33) score (OR 2.482; 95% CI [1.126-5.47], p = 0.024). In the multivariate analyses, age, interval from CT completion, type and number of CT courses were not significantly associated with CIPN score (OR 5.165, 95% CI [0.478-55.83], p = 0.176).
Persistent CIPN is common among ovarian cancer long-term survivors. CYP2C8_rs1934951 SNP may be associated with severe residual CIPN in EOC survivors. More studies are warranted to identify predictive factors of CIPN.
方法:Vivrovaire是法国多中心队列研究,研究了CT完成后3年无疾病的EOC患者。使用FACT/GOG-Ntx4自我问卷评估PersistentCIPN。评估了所选基因中纯合(hom)或杂合(het)单核苷酸多态性(SNP)的关联。
结果:130例患者被纳入,CT完成的中位时间为63[35-180]个月。medianCIPN得分为37[18-44],35例(26.9%)患者报告严重CIPN(<33)。SNP鉴定如下:CYP2C8[hom,n=32(24.6%)/het,n=99,(76.2%)];CYP3A4[hom,n=0(0%)/het,n=8(6.2%)],ERCC1[hom,n=21(16.2%)/het,n=57(43.8%)],和XPC[hom,n=45(34.6%)/het,n=66(50.8%)]。在单变量分析中,≥1个homSNP的鉴定与较低的CIPN评分相关(连续变量;p=0.045).携带hom或hetCYP2C8_rs1934951SNP的患者报告更可能严重CIPN(阈值<33)评分(OR2.482;95%CI[1.126-5.47],p=0.024)。在多变量分析中,年龄,从CT完成的间隔,CT病程的类型和数量与CIPN评分无显著相关(OR5.165,95%CI[0.478-55.83],p=0.176)。
结论:持续CIPN在卵巢癌长期存活者中很常见。CYP2C8_rs1934951SNP可能与EOC幸存者的严重残留CIPN相关。有必要进行更多的研究来确定CIPN的预测因素。