Abstract：
Recently, malignant neoplasms have growingly caused human morbidity and mortality. Head and neck cancer (HNC) constitutes a substantial group of malignancies occurring in various anatomical regions of the head and neck, including lips, mouth, throat, larynx, nose, sinuses, oropharynx, hypopharynx, nasopharynx, and salivary glands. The present study addresses the phosphoinositide 3-kinase (PI3K)/protein kinase B (Akt)/mammalian target of rapamycin (mTOR) pathway as a possible therapeutic target in cancer therapy. Finding new multitargeting agents capable of modulating PI3K/Akt/mTOR and cross-linked mediators could be viewed as an effective strategy in combating HNC. Recent studies have introduced phytochemicals as multitargeting agents and rich sources for finding and developing new therapeutic agents. Phytochemicals have exhibited immense anticancer effects, including targeting different stages of HNC through the modulation of several signaling pathways. Moreover, phenolic/polyphenolic compounds, alkaloids, terpenes/terpenoids, and other secondary metabolites have demonstrated promising anticancer activities because of their diverse pharmacological and biological properties like antiproliferative, antineoplastic, antioxidant, and anti-inflammatory activities. The current review is mainly focused on new therapeutic strategies for HNC passing through the PI3K/Akt/mTOR pathway as new strategies in combating HNC.
摘要：
最近,恶性肿瘤越来越引起人类发病和死亡。头颈部癌（HNC）构成了发生在头颈部各个解剖区域的大量恶性肿瘤，包括嘴唇,嘴，喉咙,喉部,鼻子,鼻窦,口咽,下咽,鼻咽部,和唾液腺.本研究将磷酸肌醇3激酶（PI3K）/蛋白激酶B（Akt）/哺乳动物雷帕霉素靶标（mTOR）途径作为癌症治疗中可能的治疗靶标。发现能够调节PI3K/Akt/mTOR和交联介质的新的多靶向试剂可以被视为对抗HNC的有效策略。最近的研究已经引入植物化学物质作为多靶向剂和用于发现和开发新的治疗剂的丰富来源。植物化学物质表现出巨大的抗癌作用，包括通过调节几种信号通路靶向不同阶段的HNC。此外，酚类/多酚化合物，生物碱，萜类/萜类化合物，和其他次生代谢物已经证明了有希望的抗癌活性，因为它们不同的药理和生物学特性，如抗增殖，抗肿瘤,抗氧化剂，和抗炎活性。当前的综述主要集中在通过PI3K/Akt/mTOR途径的HNC的新治疗策略作为对抗HNC的新策略。
