Abstract：
Polycythemia vera (PV) is a chronic myeloproliferative disorder characterized by uncontrolled red blood cell production. Megaloblastic anemia is caused by deficiency of cobalamin (vitamin B12) and/or folate (vitamin B9). While B12 deficiency may be caused by insufficient dietary intake or impairment of its utilization, its association with PV is described without exact knowledge of the physiopathology. We herein report the occurrence of megaloblastic anemia due to Vitamin B12 deficiency in an 85-year-old North African woman patient with PV. This case highlights this atypical presentation of PV and challenges that comes with it causing the delay of diagnosis and the complexity of its diagnosis and treatment. Keywords: megaloblastic anemia, polycythemia vera, association, case report.
摘要：
真性红细胞增多症（PV）是一种慢性骨髓增殖性疾病，其特征是红细胞产生不受控制。巨幼细胞性贫血是由钴胺素（维生素B12）和/或叶酸（维生素B9）缺乏引起的。虽然B12缺乏可能是由膳食摄入不足或其利用受损引起的，它与PV的关联被描述为没有确切的病理生理学知识。我们在此报告了一名85岁的北非女性PV患者由于维生素B12缺乏引起的巨幼细胞性贫血的发生。该病例突出了PV的这种非典型表现以及随之而来的挑战，导致诊断延迟以及诊断和治疗的复杂性。关键词：巨幼细胞性贫血，真性红细胞增多症,协会,病例报告。
