PDF(Pubmed)
Abstract：
BACKGROUND: Chronic obstructive pulmonary disease (COPD) and bronchial asthma pose significant threats and challenges to global health care, emphasizing the need for precise inhaler therapies to overcome this burden. The optimal peak inspiratory flow rate (PIFR) is a crucial determinant for the right selection and effective use of an inhaler device. It also helps to improve the treatment effectiveness of obstructive airway diseases worldwide as it allows effective drug delivery to distal airways and lung parenchyma. It is used as a selection criterion by physicians around the world for selecting personalized inhaler devices.
OBJECTIVE: To find out the optimal and non-optimal PIFR prevalence and its influencing factors in stable and exacerbation phases of COPD and bronchial asthma in Tamil Nadu, India.
METHODS: It is a single-center, observational, cross-sectional study conducted from February 2022 to August 2023. The patients who meet the diagnostic criteria specified by the Global Initiative for Chronic Obstructive Lung Disease (GOLD) guidelines for COPD and the Global Initiative for Asthma (GINA) guidelines for bronchial asthma are enrolled in our study. The PIFR was measured using a hand-held digital spirometry device, along with demographic data collection. Statistical analyses, including t-tests and chi-square tests, were performed using SPSS version 21 (IBM Corp., Armonk, NY).
RESULTS: Gender, height, and disease severity significantly impacted the PIFR. Females, normal BMI individuals, and those with moderate disease severity exhibited higher optimal PIFR rates. Stable or exacerbation phases, disease, and smoking status do not influence either optimal or non-optimal PIFR. Notably, substantial differences in lung function parameters were observed between optimal (60-90 L/min) and non-optimal PIFR (insufficient: <30 L/min, suboptimal: 30-60 L/min, excessive: >90 L/min) groups, highlighting their impact on respiratory health.
CONCLUSIONS: This study emphasizes the importance of personalized inhaler strategies, considering gender, height, and disease severity. Proper inhaler device selection, continuous monitoring of inhaler technique, and tailored inhaler education at every OPD visit are vital for optimizing effective COPD and bronchial asthma management and improving adherence to treatment.
OBJECTIVE: To find out the optimal and non-optimal PIFR prevalence and its influencing factors in stable and exacerbation phases of COPD and bronchial asthma in Tamil Nadu, India.
METHODS: It is a single-center, observational, cross-sectional study conducted from February 2022 to August 2023. The patients who meet the diagnostic criteria specified by the Global Initiative for Chronic Obstructive Lung Disease (GOLD) guidelines for COPD and the Global Initiative for Asthma (GINA) guidelines for bronchial asthma are enrolled in our study. The PIFR was measured using a hand-held digital spirometry device, along with demographic data collection. Statistical analyses, including t-tests and chi-square tests, were performed using SPSS version 21 (IBM Corp., Armonk, NY).
RESULTS: Gender, height, and disease severity significantly impacted the PIFR. Females, normal BMI individuals, and those with moderate disease severity exhibited higher optimal PIFR rates. Stable or exacerbation phases, disease, and smoking status do not influence either optimal or non-optimal PIFR. Notably, substantial differences in lung function parameters were observed between optimal (60-90 L/min) and non-optimal PIFR (insufficient: <30 L/min, suboptimal: 30-60 L/min, excessive: >90 L/min) groups, highlighting their impact on respiratory health.
CONCLUSIONS: This study emphasizes the importance of personalized inhaler strategies, considering gender, height, and disease severity. Proper inhaler device selection, continuous monitoring of inhaler technique, and tailored inhaler education at every OPD visit are vital for optimizing effective COPD and bronchial asthma management and improving adherence to treatment.
摘要：
背景：慢性阻塞性肺疾病（COPD）和支气管哮喘对全球卫生保健构成重大威胁和挑战，强调需要精确的吸入疗法来克服这一负担。最佳峰值吸气流速(PIFR)是正确选择和有效使用吸入器装置的关键决定因素。它还有助于提高全球阻塞性气道疾病的治疗效果，因为它可以有效地将药物输送到远端气道和肺实质。它被世界各地的医生用作选择个性化吸入器装置的选择标准。
目的：了解泰米尔纳德邦COPD和支气管哮喘稳定期和加重期的最佳和非最佳PIFR患病率及其影响因素，印度。
方法：它是单中心，观察,2022年2月至2023年8月进行的横断面研究。符合慢性阻塞性肺疾病全球倡议（GOLD）指南和支气管哮喘全球倡议（GINA）指南指定的诊断标准的患者纳入我们的研究。使用手持式数字肺活量测定装置测量PIFR，以及人口统计数据收集。统计分析，包括t检验和卡方检验，使用SPSS版本21(IBMCorp.,Armonk,NY).
结果：性别，高度,和疾病严重程度显著影响PIFR。雌性,正常的BMI个体，中度疾病严重程度的患者表现出更高的最佳PIFR率。稳定或恶化阶段，疾病,吸烟状况不会影响最佳或非最佳PIFR。值得注意的是,在最佳（60-90L/min）和非最佳PIFR（不足：<30L/min，次优：30-60升/分钟，过量：>90L/min）组，强调它们对呼吸健康的影响。
结论：本研究强调个性化吸入器策略的重要性，考虑到性别，高度,和疾病的严重程度。正确选择吸入器装置，连续监测吸入器技术，在每次OPD访视中进行量身定制的吸入器教育对于优化有效的COPD和支气管哮喘管理以及提高治疗依从性至关重要.
目的：了解泰米尔纳德邦COPD和支气管哮喘稳定期和加重期的最佳和非最佳PIFR患病率及其影响因素，印度。
方法：它是单中心，观察,2022年2月至2023年8月进行的横断面研究。符合慢性阻塞性肺疾病全球倡议（GOLD）指南和支气管哮喘全球倡议（GINA）指南指定的诊断标准的患者纳入我们的研究。使用手持式数字肺活量测定装置测量PIFR，以及人口统计数据收集。统计分析，包括t检验和卡方检验，使用SPSS版本21(IBMCorp.,Armonk,NY).
结果：性别，高度,和疾病严重程度显著影响PIFR。雌性,正常的BMI个体，中度疾病严重程度的患者表现出更高的最佳PIFR率。稳定或恶化阶段，疾病,吸烟状况不会影响最佳或非最佳PIFR。值得注意的是,在最佳（60-90L/min）和非最佳PIFR（不足：<30L/min，次优：30-60升/分钟，过量：>90L/min）组，强调它们对呼吸健康的影响。
结论：本研究强调个性化吸入器策略的重要性，考虑到性别，高度,和疾病的严重程度。正确选择吸入器装置，连续监测吸入器技术，在每次OPD访视中进行量身定制的吸入器教育对于优化有效的COPD和支气管哮喘管理以及提高治疗依从性至关重要.
