Abstract：
UNASSIGNED: Atherosclerotic cardiovascular disease (ASCVD) is a major health concern, and lipoprotein(a) (Lp(a)) is an independent risk factor. However, there is limited evidence regarding Lp(a) and the risk of ASCVD in Asian populations. This study aimed to assess the predictive value of changes in coronary artery calcification (CAC) for ASCVD risk associated with Lp(a) level.
UNASSIGNED: Participants (n=2,750) were grouped according to their Lp(a) levels, and the association between Lp(a) and CAC progression was examined. CAC progression was defined as the occurrence of incident CAC or a difference ≥2.5 between the square root (√) of baseline and follow-up coronary artery calcium scores (CACSs) (Δ√transformed CACS). To adjust for differences in follow-up periods, Δ√transformed CACS was divided by the follow- up period (in years).
UNASSIGNED: Over an average follow-up of 3.07 years, 18.98% of participants experienced CAC progression. Those with disease progression had notably higher Lp(a) levels. Higher Lp(a) tertiles correlated with increased baseline and follow-up CACS, CAC progression (%), and Δ√transformed CACS. Even after adjustment, higher Lp(a) levels were associated with CAC progression. However, annualized Δ√transformed CACS analysis yielded no significant results.
UNASSIGNED: This study demonstrated an association between elevated Lp(a) levels and CAC progression in a general population without ASCVD. However, longer-term follow-up studies are needed to obtain meaningful results regarding CAC progression. Further research is necessary to utilize Lp(a) level as a predictor of cardiovascular disease and to establish clinically relevant thresholds specific to the Korean population.
UNASSIGNED: Participants (n=2,750) were grouped according to their Lp(a) levels, and the association between Lp(a) and CAC progression was examined. CAC progression was defined as the occurrence of incident CAC or a difference ≥2.5 between the square root (√) of baseline and follow-up coronary artery calcium scores (CACSs) (Δ√transformed CACS). To adjust for differences in follow-up periods, Δ√transformed CACS was divided by the follow- up period (in years).
UNASSIGNED: Over an average follow-up of 3.07 years, 18.98% of participants experienced CAC progression. Those with disease progression had notably higher Lp(a) levels. Higher Lp(a) tertiles correlated with increased baseline and follow-up CACS, CAC progression (%), and Δ√transformed CACS. Even after adjustment, higher Lp(a) levels were associated with CAC progression. However, annualized Δ√transformed CACS analysis yielded no significant results.
UNASSIGNED: This study demonstrated an association between elevated Lp(a) levels and CAC progression in a general population without ASCVD. However, longer-term follow-up studies are needed to obtain meaningful results regarding CAC progression. Further research is necessary to utilize Lp(a) level as a predictor of cardiovascular disease and to establish clinically relevant thresholds specific to the Korean population.
摘要：
■动脉粥样硬化性心血管疾病（ASCVD）是一个主要的健康问题，脂蛋白(a)(Lp(a))是独立的危险因素。然而,关于亚洲人群中Lp(a)和ASCVD风险的证据有限.本研究旨在评估冠状动脉钙化（CAC）变化对与Lp（a）水平相关的ASCVD风险的预测价值。
■参与者（n=2,750）根据其Lp（a）水平进行分组，并检查Lp（a）与CAC进展之间的关联。CAC进展定义为事件CAC的发生或基线与随访冠状动脉钙积分（CACSs）的平方根（√）之间的差异≥2.5（Δ√转换CACS）。为了调整后续期间的差异，Δ√变换的CACS除以随访期(以年为单位)。
■平均随访3.07年，18.98%的参与者经历了CAC进展。疾病进展的患者Lp（a）水平明显较高。较高的Lp（a）三元率与基线和随访CACS增加相关，CAC进展（%），和Δ√变换的CACS。即使经过调整，较高的Lp(a)水平与CAC进展相关.然而,年化Δ√转化CACS分析没有显著结果。
■这项研究表明，在没有ASCVD的普通人群中，Lp（a）水平升高与CAC进展之间存在关联。然而,需要进行长期随访研究,以获得有关CAC进展的有意义的结果.需要进一步的研究来利用Lp（a）水平作为心血管疾病的预测因子，并建立特定于韩国人群的临床相关阈值。
■参与者（n=2,750）根据其Lp（a）水平进行分组，并检查Lp（a）与CAC进展之间的关联。CAC进展定义为事件CAC的发生或基线与随访冠状动脉钙积分（CACSs）的平方根（√）之间的差异≥2.5（Δ√转换CACS）。为了调整后续期间的差异，Δ√变换的CACS除以随访期(以年为单位)。
■平均随访3.07年，18.98%的参与者经历了CAC进展。疾病进展的患者Lp（a）水平明显较高。较高的Lp（a）三元率与基线和随访CACS增加相关，CAC进展（%），和Δ√变换的CACS。即使经过调整，较高的Lp(a)水平与CAC进展相关.然而,年化Δ√转化CACS分析没有显著结果。
■这项研究表明，在没有ASCVD的普通人群中，Lp（a）水平升高与CAC进展之间存在关联。然而,需要进行长期随访研究,以获得有关CAC进展的有意义的结果.需要进一步的研究来利用Lp（a）水平作为心血管疾病的预测因子，并建立特定于韩国人群的临床相关阈值。
