UNASSIGNED: Participants (n=2,750) were grouped according to their Lp(a) levels, and the association between Lp(a) and CAC progression was examined. CAC progression was defined as the occurrence of incident CAC or a difference ≥2.5 between the square root (√) of baseline and follow-up coronary artery calcium scores (CACSs) (Δ√transformed CACS). To adjust for differences in follow-up periods, Δ√transformed CACS was divided by the follow- up period (in years).
UNASSIGNED: Over an average follow-up of 3.07 years, 18.98% of participants experienced CAC progression. Those with disease progression had notably higher Lp(a) levels. Higher Lp(a) tertiles correlated with increased baseline and follow-up CACS, CAC progression (%), and Δ√transformed CACS. Even after adjustment, higher Lp(a) levels were associated with CAC progression. However, annualized Δ√transformed CACS analysis yielded no significant results.
UNASSIGNED: This study demonstrated an association between elevated Lp(a) levels and CAC progression in a general population without ASCVD. However, longer-term follow-up studies are needed to obtain meaningful results regarding CAC progression. Further research is necessary to utilize Lp(a) level as a predictor of cardiovascular disease and to establish clinically relevant thresholds specific to the Korean population.
■参与者(n=2,750)根据其Lp(a)水平进行分组,并检查Lp(a)与CAC进展之间的关联。CAC进展定义为事件CAC的发生或基线与随访冠状动脉钙积分(CACSs)的平方根(√)之间的差异≥2.5(Δ√转换CACS)。为了调整后续期间的差异,Δ√变换的CACS除以随访期(以年为单位)。
■平均随访3.07年,18.98%的参与者经历了CAC进展。疾病进展的患者Lp(a)水平明显较高。较高的Lp(a)三元率与基线和随访CACS增加相关,CAC进展(%),和Δ√变换的CACS。即使经过调整,较高的Lp(a)水平与CAC进展相关.然而,年化Δ√转化CACS分析没有显著结果。
■这项研究表明,在没有ASCVD的普通人群中,Lp(a)水平升高与CAC进展之间存在关联。然而,需要进行长期随访研究,以获得有关CAC进展的有意义的结果.需要进一步的研究来利用Lp(a)水平作为心血管疾病的预测因子,并建立特定于韩国人群的临床相关阈值。