Abstract：
OBJECTIVE: Critically review and summarise existing knowledge on prevalence of oral, dental, and craniofacial side-effects of antineoplastic treatment in childhood cancer survivors (CCS).
METHODS: A literature search was conducted for studies reporting on children aged 4-19 years treated for any type of malignancy up to the age of 15 years and for whom, at the time of the examination, more than 8 months have elapsed since the end of treatment. Data regarding dental late effects on teeth and craniofacial complex were collected and mean prevalence of each defect was reported.
RESULTS: From the 800 articles identified, 17 studies fulfilled inclusion criteria and were included. A total of 983 CCS were examined, with the total number of healthy controls being 1266 children. Haematological malignancy was the most prevalent diagnosis with the age at diagnosis ranging between 0-15 years. Multiple antineoplastic protocols were implemented with the elapsed time being 8 months up to 17 years. One-third of CCS experienced at least one late effect, with corresponding value for the control group being below 25%. Among the defects identified clinically, microdontia, hypodontia and enamel developmental defects were recorded in 1/4 of CCS. Impaired root growth and agenesis were the two defects mostly recorded radiographically. The effect on dental maturity and on salivary glands was unclear.
CONCLUSIONS: CCS are at risk of developing dental late effects because of their disease and its treatment and therefore, routine periodic examinations are essential to record their development and provide comprehensive oral healthcare.
METHODS: A literature search was conducted for studies reporting on children aged 4-19 years treated for any type of malignancy up to the age of 15 years and for whom, at the time of the examination, more than 8 months have elapsed since the end of treatment. Data regarding dental late effects on teeth and craniofacial complex were collected and mean prevalence of each defect was reported.
RESULTS: From the 800 articles identified, 17 studies fulfilled inclusion criteria and were included. A total of 983 CCS were examined, with the total number of healthy controls being 1266 children. Haematological malignancy was the most prevalent diagnosis with the age at diagnosis ranging between 0-15 years. Multiple antineoplastic protocols were implemented with the elapsed time being 8 months up to 17 years. One-third of CCS experienced at least one late effect, with corresponding value for the control group being below 25%. Among the defects identified clinically, microdontia, hypodontia and enamel developmental defects were recorded in 1/4 of CCS. Impaired root growth and agenesis were the two defects mostly recorded radiographically. The effect on dental maturity and on salivary glands was unclear.
CONCLUSIONS: CCS are at risk of developing dental late effects because of their disease and its treatment and therefore, routine periodic examinations are essential to record their development and provide comprehensive oral healthcare.
摘要：
目的：严格回顾和总结现有的知识，牙科,和儿童癌症幸存者（CCS）抗肿瘤治疗的颅面副作用。
方法：对报道4-19岁儿童的研究进行了文献检索，这些儿童治疗了15岁以下的任何类型的恶性肿瘤，在考试的时候,治疗结束后已超过8个月。收集了有关牙齿和颅面复合体的牙齿后期影响的数据，并报告了每种缺陷的平均患病率。
结果：从确定的800篇文章中，17项研究符合纳入标准并被纳入。共检查了983个CCS，健康对照者总数为1266名儿童。血液恶性肿瘤是最普遍的诊断，诊断年龄在0-15岁之间。实施了多种抗肿瘤方案，时间为8个月至17年。三分之一的CCS经历了至少一个后期效应，对照组的相应值低于25%。在临床发现的缺陷中，microdontia,在1/4的CCS中记录到牙体发育不全和牙釉质发育缺陷。根系生长和发育不全是影像学记录的两个缺陷。对牙齿成熟度和唾液腺的影响尚不清楚。
结论：CCS由于其疾病及其治疗而有发展牙齿晚期效应的风险，因此，常规定期检查对于记录其发展和提供全面的口腔保健至关重要。
方法：对报道4-19岁儿童的研究进行了文献检索，这些儿童治疗了15岁以下的任何类型的恶性肿瘤，在考试的时候,治疗结束后已超过8个月。收集了有关牙齿和颅面复合体的牙齿后期影响的数据，并报告了每种缺陷的平均患病率。
结果：从确定的800篇文章中，17项研究符合纳入标准并被纳入。共检查了983个CCS，健康对照者总数为1266名儿童。血液恶性肿瘤是最普遍的诊断，诊断年龄在0-15岁之间。实施了多种抗肿瘤方案，时间为8个月至17年。三分之一的CCS经历了至少一个后期效应，对照组的相应值低于25%。在临床发现的缺陷中，microdontia,在1/4的CCS中记录到牙体发育不全和牙釉质发育缺陷。根系生长和发育不全是影像学记录的两个缺陷。对牙齿成熟度和唾液腺的影响尚不清楚。
结论：CCS由于其疾病及其治疗而有发展牙齿晚期效应的风险，因此，常规定期检查对于记录其发展和提供全面的口腔保健至关重要。
