PDF(Pubmed)
Abstract：
OBJECTIVE: To assess whether patients from minority ethnic groups have different perceptions about the quality-of-life outcomes that matter most to them.
METHODS: Cross-sectional observational study.
METHODS: High volume eye centres serving the most ethnically diverse region in the UK, recruiting from July 2021 to February 2022.
METHODS: 511 patients with primary open-angle glaucoma and the predisease state of ocular hypertension.
METHODS: The main outcome was participants\' self-reported priorities for health outcomes.
RESULTS: Participants fell into one of four clusters with differing priorities for health outcomes, namely: (1) vision, (2) drop freedom, (3) intraocular pressure and (4) one-time treatment. Ethnicity was the strongest determinant of cluster membership after adjusting for potential confounders. Compared with white patients prioritising vision alone, the OR for black/black British patients was 7.31 (95% CI 3.43 to 15.57, p<0.001) for prioritising drop freedom; 5.95 (2.91 to 12.16, p<0.001) for intraocular pressure; and 2.99 (1.44 to 6.18, p=0.003) for one-time treatment. For Asian/Asian British patients, the OR was 3.17 (1.12 to 8.96, p=0.030) for prioritising intraocular pressure as highly as vision. Other ethnic minority groups also had higher ORs for prioritising health outcomes other than vision alone: 4.50 (1.03 to 19.63, p=0.045) for drop freedom and 5.37 (1.47 to 19.60, p=0.011) for intraocular pressure.
CONCLUSIONS: Ethnicity is strongly associated with differing perceptions about the health outcomes that matter. An individualised and ethnically inclusive approach is needed when selecting and evaluating treatments in clinical and research settings.
METHODS: Cross-sectional observational study.
METHODS: High volume eye centres serving the most ethnically diverse region in the UK, recruiting from July 2021 to February 2022.
METHODS: 511 patients with primary open-angle glaucoma and the predisease state of ocular hypertension.
METHODS: The main outcome was participants\' self-reported priorities for health outcomes.
RESULTS: Participants fell into one of four clusters with differing priorities for health outcomes, namely: (1) vision, (2) drop freedom, (3) intraocular pressure and (4) one-time treatment. Ethnicity was the strongest determinant of cluster membership after adjusting for potential confounders. Compared with white patients prioritising vision alone, the OR for black/black British patients was 7.31 (95% CI 3.43 to 15.57, p<0.001) for prioritising drop freedom; 5.95 (2.91 to 12.16, p<0.001) for intraocular pressure; and 2.99 (1.44 to 6.18, p=0.003) for one-time treatment. For Asian/Asian British patients, the OR was 3.17 (1.12 to 8.96, p=0.030) for prioritising intraocular pressure as highly as vision. Other ethnic minority groups also had higher ORs for prioritising health outcomes other than vision alone: 4.50 (1.03 to 19.63, p=0.045) for drop freedom and 5.37 (1.47 to 19.60, p=0.011) for intraocular pressure.
CONCLUSIONS: Ethnicity is strongly associated with differing perceptions about the health outcomes that matter. An individualised and ethnically inclusive approach is needed when selecting and evaluating treatments in clinical and research settings.
摘要：
目的：评估少数民族患者对生活质量结果是否有不同的看法，这对他们来说是最重要的。
方法：横断面观察性研究。
方法：为英国种族最多样化的地区服务的高容量眼部中心，从2021年7月到2022年2月招募。
方法：511例原发性开角型青光眼患者和高眼压病前状态。
方法：主要结果是参与者自我报告的健康结果优先事项。
结果：参与者分为四个对健康结果具有不同优先级的集群之一，即：（1）视觉，（2）下降自由，（3）眼压和（4）一次性治疗。在调整了潜在的混杂因素后，种族是集群成员资格的最强决定因素。与仅优先考虑视力的白人患者相比，黑人/黑人英国患者的OR为7.31(95%CI3.43~15.57,p<0.001),优先考虑跌落自由度;眼压为5.95(2.91~12.16,p<0.001);一次性治疗为2.99(1.44~6.18,p=0.003).对于亚裔/亚裔英国患者，将眼压优先于视力的OR为3.17(1.12~8.96,p=0.030).除视力外，其他少数民族在优先考虑健康结果方面也有较高的OR值：4.50（1.03至19.63，p=0.045）的下降自由度和5.37（1.47至19.60，p=0.011）的眼压。
结论：种族与对重要的健康结果的不同看法密切相关。在临床和研究环境中选择和评估治疗方法时，需要个性化和种族包容性的方法。
方法：横断面观察性研究。
方法：为英国种族最多样化的地区服务的高容量眼部中心，从2021年7月到2022年2月招募。
方法：511例原发性开角型青光眼患者和高眼压病前状态。
方法：主要结果是参与者自我报告的健康结果优先事项。
结果：参与者分为四个对健康结果具有不同优先级的集群之一，即：（1）视觉，（2）下降自由，（3）眼压和（4）一次性治疗。在调整了潜在的混杂因素后，种族是集群成员资格的最强决定因素。与仅优先考虑视力的白人患者相比，黑人/黑人英国患者的OR为7.31(95%CI3.43~15.57,p<0.001),优先考虑跌落自由度;眼压为5.95(2.91~12.16,p<0.001);一次性治疗为2.99(1.44~6.18,p=0.003).对于亚裔/亚裔英国患者，将眼压优先于视力的OR为3.17(1.12~8.96,p=0.030).除视力外，其他少数民族在优先考虑健康结果方面也有较高的OR值：4.50（1.03至19.63，p=0.045）的下降自由度和5.37（1.47至19.60，p=0.011）的眼压。
结论：种族与对重要的健康结果的不同看法密切相关。在临床和研究环境中选择和评估治疗方法时，需要个性化和种族包容性的方法。
