Abstract：
BACKGROUND: Mindfulness-based treatments gained popularity for migraine treatment. In this manuscript we report the results of a single-arm open pilot study that evaluated the impact of a multimodal web-based intervention combining home-based medication withdrawal, patients\' education, and online mindfulness-based interventions. We aimed to address whether our program had the ability to show a change in the observed parameters and the study should therefore be intended as an early phase trial.
METHODS: Consecutive patients with chronic migraine associated with medication overuse headache were enrolled, followed-up for 12 months, in a program that included home-based medication withdrawal, education on the correct use of drugs and lifestyle issues, prescription of tailored pharmacological prophylaxis, and attendance to six online mindfulness-based sessions. We tested the effect of the program on improving headache frequency, medication intake, quality of life (QoL), headache impact, depression, self-efficacy, and pain catastrophizing.
RESULTS: A total of 37 patients completed the study (10 dropped out). We observed a large improvement in headache frequency, medication intake, headache impact, and QoL, a moderate improvement in pain catastrophizing and a mild improvement in depression symptoms; 70% to 76% of patients achieved 50% or more reduction in headache frequency from baseline to each follow-up (p < .01).
CONCLUSIONS: The results of our multimodal program showed significant improvements in headache frequency, medication intake, and patient-reported outcomes. Future studies are needed to better identify patients who might benefit most from Digital Health Interventions and to demonstrate at least an equivalence in outcome with in-person programs carried out in hospital settings.
METHODS: Consecutive patients with chronic migraine associated with medication overuse headache were enrolled, followed-up for 12 months, in a program that included home-based medication withdrawal, education on the correct use of drugs and lifestyle issues, prescription of tailored pharmacological prophylaxis, and attendance to six online mindfulness-based sessions. We tested the effect of the program on improving headache frequency, medication intake, quality of life (QoL), headache impact, depression, self-efficacy, and pain catastrophizing.
RESULTS: A total of 37 patients completed the study (10 dropped out). We observed a large improvement in headache frequency, medication intake, headache impact, and QoL, a moderate improvement in pain catastrophizing and a mild improvement in depression symptoms; 70% to 76% of patients achieved 50% or more reduction in headache frequency from baseline to each follow-up (p < .01).
CONCLUSIONS: The results of our multimodal program showed significant improvements in headache frequency, medication intake, and patient-reported outcomes. Future studies are needed to better identify patients who might benefit most from Digital Health Interventions and to demonstrate at least an equivalence in outcome with in-person programs carried out in hospital settings.
摘要：
背景：基于正念的治疗在偏头痛治疗中越来越受欢迎。在这份手稿中，我们报告了一项单臂开放式试点研究的结果，该研究评估了基于网络的多模式干预结合家庭药物戒断的影响。患者教育，和基于在线正念的干预措施。我们旨在解决我们的程序是否有能力显示观察参数的变化，因此该研究应作为早期阶段试验。
方法：连续纳入与药物过度使用头痛相关的慢性偏头痛患者，随访12个月,在一个包括家庭停药的项目中，关于正确使用药物和生活方式问题的教育，定制的药物预防处方，参加六个在线正念课程。我们测试了该计划对改善头痛频率的影响，药物摄入量，生活质量（QoL），头痛的影响，抑郁症,自我效能感,痛苦的灾难。
结果：共有37名患者完成了研究（10名退出）。我们观察到头痛频率有了很大的改善，药物摄入量，头痛的影响，和QoL,疼痛灾难化中度改善,抑郁症状轻度改善;从基线到每次随访,70%~76%的患者头痛频率减少50%或更多(p<.01).
结论：我们的多模式项目结果显示头痛频率显著改善，药物摄入量，和患者报告的结果。需要进行未来的研究，以更好地识别可能从数字健康干预中受益最大的患者，并至少证明与在医院环境中进行的面对面计划的结果等效。
方法：连续纳入与药物过度使用头痛相关的慢性偏头痛患者，随访12个月,在一个包括家庭停药的项目中，关于正确使用药物和生活方式问题的教育，定制的药物预防处方，参加六个在线正念课程。我们测试了该计划对改善头痛频率的影响，药物摄入量，生活质量（QoL），头痛的影响，抑郁症,自我效能感,痛苦的灾难。
结果：共有37名患者完成了研究（10名退出）。我们观察到头痛频率有了很大的改善，药物摄入量，头痛的影响，和QoL,疼痛灾难化中度改善,抑郁症状轻度改善;从基线到每次随访,70%~76%的患者头痛频率减少50%或更多(p<.01).
结论：我们的多模式项目结果显示头痛频率显著改善，药物摄入量，和患者报告的结果。需要进行未来的研究，以更好地识别可能从数字健康干预中受益最大的患者，并至少证明与在医院环境中进行的面对面计划的结果等效。
