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Abstract：
BACKGROUND: The rising prevalence of insulin resistance (IR), obesity, and its complications in India is due to lifestyle changes, eating patterns, stress, and genetic factors. Markers for IR are often expensive, invasive, or impractical for use in economically disadvantaged or remote areas. To address this, we evaluated the efficacy of the triglyceride to high-density lipoprotein (TG/HDL) ratio as a simple, reliable, accessible, and affordable surrogate marker of IR in comparison to the homeostatic model assessment for insulin resistance (HOMA-IR).
METHODS: This cross-sectional observational study was performed at a tertiary care center in central India and included 815 subjects aged 18 to 60 years after excluding those with systemic diseases, drugs affecting weight, or pregnant or lactating women. Descriptive and inferential statistical analysis was done to represent the study findings.
RESULTS: Males and obese subjects were more insulin resistant than females and non-obese subjects, respectively. The TG/HDL had a sensitivity of 91.81%, a specificity of 92.88%, a positive predictive value of 94.46%, and a negative predictive value of 89.56%, with a diagnostic accuracy of 92.27% when compared to HOMA-IR.
CONCLUSIONS: We concluded that TG/HDL serves as a simple, affordable, and accurate marker of IR in a diverse population of central India. There is a definite scope to use the same for large-scale screening, epidemiological research, and routine clinical practice.
METHODS: This cross-sectional observational study was performed at a tertiary care center in central India and included 815 subjects aged 18 to 60 years after excluding those with systemic diseases, drugs affecting weight, or pregnant or lactating women. Descriptive and inferential statistical analysis was done to represent the study findings.
RESULTS: Males and obese subjects were more insulin resistant than females and non-obese subjects, respectively. The TG/HDL had a sensitivity of 91.81%, a specificity of 92.88%, a positive predictive value of 94.46%, and a negative predictive value of 89.56%, with a diagnostic accuracy of 92.27% when compared to HOMA-IR.
CONCLUSIONS: We concluded that TG/HDL serves as a simple, affordable, and accurate marker of IR in a diverse population of central India. There is a definite scope to use the same for large-scale screening, epidemiological research, and routine clinical practice.
摘要：
背景：胰岛素抵抗（IR）患病率上升，肥胖，它在印度的并发症是由于生活方式的改变，饮食模式，压力，和遗传因素。IR的标记通常很昂贵，侵入性,或在经济困难或偏远地区使用不切实际。为了解决这个问题，我们评估了甘油三酯与高密度脂蛋白（TG/HDL）比值的疗效，可靠,可访问,与胰岛素抵抗的稳态模型评估（HOMA-IR）相比，以及负担得起的IR替代标记。
方法：这项横断面观察研究是在印度中部的一家三级护理中心进行的，包括815名年龄在18至60岁之间的受试者，这些受试者在排除了患有全身性疾病的人群后，影响体重的药物,或怀孕或哺乳期妇女。进行描述性和推断性统计分析以代表研究结果。
结果：男性和肥胖受试者的胰岛素抵抗程度高于女性和非肥胖受试者，分别。TG/HDL的灵敏度为91.81%,特异性为92.88%，阳性预测值为94.46%，阴性预测值为89.56%，与HOMA-IR相比，诊断准确率为92.27%。
结论：我们得出结论，TG/HDL是一种简单的，负担得起的,以及印度中部不同人口中IR的准确标记。大规模筛查有一定的使用范围，流行病学研究,和常规临床实践。
方法：这项横断面观察研究是在印度中部的一家三级护理中心进行的，包括815名年龄在18至60岁之间的受试者，这些受试者在排除了患有全身性疾病的人群后，影响体重的药物,或怀孕或哺乳期妇女。进行描述性和推断性统计分析以代表研究结果。
结果：男性和肥胖受试者的胰岛素抵抗程度高于女性和非肥胖受试者，分别。TG/HDL的灵敏度为91.81%,特异性为92.88%，阳性预测值为94.46%，阴性预测值为89.56%，与HOMA-IR相比，诊断准确率为92.27%。
结论：我们得出结论，TG/HDL是一种简单的，负担得起的,以及印度中部不同人口中IR的准确标记。大规模筛查有一定的使用范围，流行病学研究,和常规临床实践。
