PDF(Pubmed)
Abstract：
The over-use of anti-parasitic compounds as a method of control has led to insufficient effectiveness and widespread drug resistance worldwide. The aim of this study was to investigate the efficacy of albendazole and levamisole as anti-parasitic agents in a lung worm control program in goat flocks. During 2021 and 2022, a total of 110 goats (age of four months and above) were randomly selected from 11 herds in the north-western region of Iran including Saanen breed (both sexes of the same age). The results indicated that 3.60, 50.80 and 41.90% were respectively infected with Dictyocaulus filaria, Muellerius capillaris and Proto-strongylus rufescens, and generally all the lung parasites in goats of this region were resistant to albendazole and levamisole. Due to clinical importance of D. filaria in goats, the molecular analysis of two samples was also done. Sequencing results showed that the identified parasites were 100% similar to the reference sequences registered in the GenBank®. The results of this research showed low level of these anthelmintics efficacy against Dictyocaulus and Muellerius. Generally, the lung parasites in goats of this region are resistant to albendazole and levamisole. The P. rufescens showed high resistance to these drugs. Totally, it can be concluded that the level of drug resistance varies in different parts of the world; but, the frequencies of drug resistance in different parts of the world are not the same, requiring more studies.
摘要：
作为控制方法的抗寄生虫化合物的过度使用已导致全世界的效力不足和广泛的耐药性。这项研究的目的是研究阿苯达唑和左旋咪唑在山羊群肺蠕虫控制计划中作为抗寄生虫剂的功效。在2021年和2022年期间，从伊朗西北地区的11只羊群中随机选择了110只山羊（4个月及以上的年龄），其中包括Saanen品种（两种性别相同）。结果表明，丝裂藻感染率分别为3.60％，50.80％和41.90％，Muellerius毛细血管和proto-strongylusrufescens，一般来说，该地区山羊的所有肺寄生虫都对阿苯达唑和左旋咪唑有抗药性。由于毛虫在山羊中的临床重要性，还对两个样品进行了分子分析。测序结果显示,所鉴定的寄生虫与GenBank®中登记的参考序列100%相似。这项研究的结果表明，这些驱虫药对网眼和Muellerius的疗效较低。一般来说,该地区山羊的肺寄生虫对阿苯达唑和左旋咪唑具有抗性。红叶假单胞菌对这些药物表现出很高的抗性。完全正确,可以得出结论，世界不同地区的抗药性水平各不相同；但是，世界不同地区的耐药频率是不一样的，需要更多的研究。
