PDF(Pubmed)
Abstract：
The maintenance of normal vascular function and homeostasis is largely dependent on the signaling mechanisms that occur within and between cells of the vasculature. TGF-β-activated kinase 1 (TAK1), a multifaceted signaling molecule, has been shown to play critical roles in various tissue types. Although the precise function of TAK1 in the vasculature remains largely unknown, emerging evidence suggests its potential involvement in both physiological and pathological processes. A comprehensive search strategy was employed to identify relevant studies, PubMed, Web of Science, and other relevant databases were systematically searched using keywords related to TAK1, TABs and MAP3K7.In this review, we discussed the role of TAK1 in vascular signaling, with a focus on its function, activation, and related signaling pathways. Specifically, we highlight the TA1-TABs complex is a key factor, regulating vascular smooth muscle cells (VSMCs) and endothelial cells (ECs) involved in the processes of inflammation, vascular proliferation and angiogenesis. This mini review aims to elucidate the evidence supporting TAK1 signaling in the vasculature, in order to better comprehend its beneficial and potential harmful effects upon TAK1 activation in vascular tissue.
摘要：
正常血管功能和体内平衡的维持在很大程度上取决于在脉管系统的细胞内和之间发生的信号传导机制。TGF-β活化激酶1(TAK1),一个多方面的信号分子，已被证明在各种组织类型中起关键作用。尽管TAK1在脉管系统中的确切功能仍然未知，新出现的证据表明，它可能参与生理和病理过程。采用全面的搜索策略来确定相关研究，PubMed,WebofScience,和其他相关数据库使用与TAK1，TABs和MAP3K7相关的关键词进行了系统搜索。在这次审查中,我们讨论了TAK1在血管信号传导中的作用，专注于它的功能，激活,以及相关的信号通路。具体来说,我们强调TA1-TABs复合物是一个关键因素，调节参与炎症过程的血管平滑肌细胞（VSMC）和内皮细胞（EC），血管增殖和血管生成。这篇小型综述旨在阐明支持血管中TAK1信号传导的证据，为了更好地理解其对血管组织中TAK1激活的有益和潜在的有害影响。
